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Long-term use of cyclosporine in liver recipients: Reduction of dosages in the first year to avoid nephrotoxicity

Iwatsuki, S and Starzl, TE and Shaw, BW and Yang, SL and Zitelli, BJ and Gartner, JC and Malatack, JJ (1983) Long-term use of cyclosporine in liver recipients: Reduction of dosages in the first year to avoid nephrotoxicity. Transplantation, 36 (6). 641 - 643. ISSN 0041-1337

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Abstract

Cyclosporine is a potent immunosuppressive drug, which has dose-related nephrotoxicity. In renal transplantation, the differentiation between rejection and toxicity is difficult and even with the aid of blood levels of the drug, it may be difficult to establish a chronic maintenance dose. Long-term survivors after liver transplantation can provide modes with which to establish maintenance doses, as these are dictated by nephrotoxicity in these patients. Twenty-nine liver transplant patients who survived one year or more were followed for changes in their cyclosporine doses. Daily oral cyclosporine dose, BUN, serum creatinine and bilirubin were monitored. The reductions in cyclosporine were dictated almost entirely by the findings of nephrotoxicity. © 1983 by The Williams and Wilkins Co.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Shaw, BW
Yang, SL
Zitelli, BJ
Gartner, JC
Malatack, JJ
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1983
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 36
Number: 6
Page Range: 641 - 643
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062114966, Starzl CV No. 528
Date Deposited: 08 Apr 2010 17:09
Last Modified: 13 Oct 2017 22:55
URI: http://d-scholarship.pitt.edu/id/eprint/3914

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