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Liver transplantation

Brown, KA (2005) Liver transplantation. In: UNSPECIFIED UNSPECIFIED, 331 - 336. ISBN UNSPECIFIED

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Purpose of review: Liver transplantation continues to change as we further define appropriate criteria for allocation and utilization of this scarce resource. The following review highlights new trends and ideas in this evolving field. Recent findings: Although the model for end-stage renal disease (MELD) scoring system appears to fairly accurately predict mortality while waiting for transplant, the system may be less accurate in predicting outcomes following transplantation. MELD scores offer an additional advantage to patients with hepatocellular carcinoma (HCC), bringing them to transplant sooner with overall better survivals. However, despite its advantages, the MELD scoring system does not resolve the disparity in the allocation of organs between various organ procurement organizations. Several variables appear to affect patients with hepatitis C undergoing liver transplantation. Selection of appropriate donors appears to be important when transplanting patients with hepatitis C virus (HCV) infection as increasing donor age is associated with poorer outcomes. However, the controversy over whether a living donor liver transplant (LDLT) results in poorer outcomes in HCV infected patients remains. Post-transplant medical treatment of HCV may result in both a sustained virologic response and improved histology. With improved overall survival in patients undergoing orthotopic liver transplant (OLT), increasing attention has been focused on the medical complications following transplant. Identifying specific contributing factors in the development of renal dysfunction and devising strategies to prevent its occurrence are critical to further improvements in outcome following OLT. Summary: As the gap between patients and available organs remains, continued investigation into appropriate allocation and maximization of outcomes following liver transplant will continue. © 2005 Lippincott Williams & Wilkins.


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Item Type: Book Section
Status: Published
CreatorsEmailPitt UsernameORCID
Brown, KA
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 May 2005
Date Type: Publication
Journal or Publication Title: Current Opinion in Gastroenterology
Volume: 21
Number: 3
Page Range: 331 - 336
DOI or Unique Handle: 10.1097/01.mog.0000159830.36793.2b
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0267-1379
Article Type: Review
Other ID: uls-drl:31735062115013, Starzl CV No. 539
Date Deposited: 08 Apr 2010 17:09
Last Modified: 02 Feb 2019 14:55


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