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Induction of hepatocyte stimulating activity by T<inf>3</inf> and appearance of the activity despite inhibition of DNA synthesis by adriamycin

Francavilla, A and Ove, P and van Thiel, DH and Coetzee, ML and Wu, SK and DiLeo, A and Starzl, TE (1984) Induction of hepatocyte stimulating activity by T<inf>3</inf> and appearance of the activity despite inhibition of DNA synthesis by adriamycin. Hormone and Metabolic Research, 16 (5). 237 - 242. ISSN 0018-5043

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Abstract

A hepatocyte stimulating activity (HSA) has been extracted from rats that had received an injection of a pharmacological dose of T 3 20 hours earlier. The injection of HSA from T 3 -treated rats into different recipient rats that had previously had 40% of their liver removed resulted in a significant increase in hepatic DNA synthesis. The injection of saline or HSA from normal rat liver had little or no effect on hepatic DNA synthesis in recipient rats. HSA from the T 3 -treated rats also stimulated DNA synthesis in Novikoff hepatoma cells and primary hepatocytes in culture, and in isolated normal rat liver nuclei in a nuclear incorporating system. In further experiments in which the increased DNA synthesis that follows partial hepatectomy was blocked by adriamycin, HSA appeared in these non-regenerating livers. This latter observation had indicated that the development of HSA is not merely an accompaniment of DNA synthesis.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Francavilla, A
Ove, P
van Thiel, DH
Coetzee, ML
Wu, SK
DiLeo, A
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 12 July 1984
Date Type: Publication
Journal or Publication Title: Hormone and Metabolic Research
Volume: 16
Number: 5
Page Range: 237 - 242
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0018-5043
Other ID: uls-drl:31735062115062, Starzl CV No. 542
Date Deposited: 08 Apr 2010 17:09
Last Modified: 16 Oct 2017 05:55
URI: http://d-scholarship.pitt.edu/id/eprint/3928

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