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Liver transplantation for biliary atresia

Iwatsuki, S and Shaw, BW and Starzl, TE (1984) Liver transplantation for biliary atresia. World Journal of Surgery, 8 (1). 51 - 56. ISSN 0364-2313

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Abstract

Orthotopic liver transplantation was performed 15 months to 20 years ago in 126 recipients, all of whom were under 18 years of age. Eighty-six of these pediatric recipients were treated before 1980 with azathioprine (or eyclophosphamide) and prednisone, to which antilymphocyte globulin (ALG) usually was added. One-year patient survival was 40%. In the last 40 cases, the new drug cyclosporine has been given with low doses of steroids. The one-year patient survival increased to 65%. Both in the pre-cyclosporine era and more recently, the survival of patients with biliary atresia has been lower than in the next largest category of patients, namely, those with liver-based inborn metabolic errors. The difficulty of operation in patients with biliary atresia has been greater than in recipients with other diagnoses, partly because of previous operations such as portoenterostomy (Kasai procedure). Hepatic portoenterostomy, worthwhile as it is, has posed technical difficulties for eventual liver transplantation, particularly when complicated Roux limb techniques or venting procedures have been applied. In our total experience the longest survival after liver replacement in a child whose original diagnosis was biliary atresia is 132/3 years. © 1984 Société Internationale de Chirurgie.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Iwatsuki, S
Shaw, BW
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 February 1984
Date Type: Publication
Journal or Publication Title: World Journal of Surgery
Volume: 8
Number: 1
Page Range: 51 - 56
DOI or Unique Handle: 10.1007/bf01658363
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0364-2313
Other ID: uls-drl:31735062115104, Starzl CV No. 547
Date Deposited: 08 Apr 2010 17:09
Last Modified: 16 Oct 2017 04:55
URI: http://d-scholarship.pitt.edu/id/eprint/3933

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