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Current status of islet xenotransplantation

Park, CG and Bottino, R and Hawthorne, WJ (2015) Current status of islet xenotransplantation. In: UNSPECIFIED UNSPECIFIED, 261 - 266. ISBN UNSPECIFIED

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Abstract

© 2015 IJS Publishing Group Limited. Cell therapy for Type 1 diabetes (T1D) utilizing islet cell transplantation can successfully restore endogenous insulin production in affected patients. Islet cell engraftment and survival are conditional on the use of efficacious anti-rejection therapies and on the availability of healthy donor cells. The scarcity of healthy human donor pancreata is a limiting factor in providing sufficient tissue to meet the demand for islet transplantation worldwide. A potential alternative to the use of cadaveric human donor pancreases is the use of animal sourced islets.Pancreatic islets obtained from pigs have emerged as an alternative to human tissues due to their great availability, physiological similarities to human islets, including the time-tested use of porcine insulin in diabetic patients and the ability to genetically modify the donor source.The evolution of refined, efficacious immunosuppressive therapies with reduced toxicity, improvements in donor management and genetic manipulation of the donor have all contributed to facilitate long-term function in pre-clinical models of pig islet grafts in non-human primates.As clinical consideration for this option is growing, and trials involving the use of porcine islets have begun, more compelling experimental data suggest that the use of pig islets may soon become a viable, safe, effective and readily available treatment for insulin deficiency in T1D patients.


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Details

Item Type: Book Section
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Park, CG
Bottino, R
Hawthorne, WJ
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 November 2015
Date Type: Publication
Journal or Publication Title: International Journal of Surgery
Volume: 23
Page Range: 261 - 266
DOI or Unique Handle: 10.1016/j.ijsu.2015.07.703
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1743-9191
Article Type: Review
Other ID: uls-drl:31735062115203, Starzl CV No. 553
Date Deposited: 08 Apr 2010 17:09
Last Modified: 13 Oct 2017 20:55
URI: http://d-scholarship.pitt.edu/id/eprint/3939

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