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Regenerating Rat Liver: Correlations Between Estrogen Receptor Localization and Deoxyribonucleic Acid Synthesis

Francavilla, A and Di Leo, A and Eagon, PK and Wu, SQ and Ove, P and Van Thiel, DH and Starzl, TE (1984) Regenerating Rat Liver: Correlations Between Estrogen Receptor Localization and Deoxyribonucleic Acid Synthesis. Gastroenterology, 86 (3). 552 - 557. ISSN 0016-5085

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Abstract

Estrogen receptor activity was quantitated in the cytosol and nucleus of normal rat liver and in regenerating rat liver at several time intervals after 75% hepatectomy. Cytosolic estradiol binding in regenerating liver decreases at 12, 24, and 48 h after hepatectomy and at 48 h is 30% of that in normal rat liver. Nuclear estrogen binding 48 h after surgery is elevated fivefold over normal values. No alterations in affinity of the receptor for estrogen have been observed. Specificity studies indicate that the estrogen receptors from both normal and regenerating liver were similar and are highly specific for estrogens. These changes in cellular distribution of receptors parallel increases in nuclear deoxyribonucleic acid synthesis and mitotic indices in the liver. © 1984, American Gastroenterological Association. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Francavilla, A
Di Leo, A
Eagon, PK
Wu, SQ
Ove, P
Van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1984
Date Type: Publication
Journal or Publication Title: Gastroenterology
Volume: 86
Number: 3
Page Range: 552 - 557
DOI or Unique Handle: 10.1016/s0016-5085(84)80027-x
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0016-5085
Other ID: uls-drl:31735062115195, Starzl CV No. 554
Date Deposited: 08 Apr 2010 17:09
Last Modified: 13 Oct 2017 21:59
URI: http://d-scholarship.pitt.edu/id/eprint/3940

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