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Pancreaticoduodenal transplantation in humans

Starzl, TE and Iwatsuki, S and Shaw, BW and Greene, DA and Van Thiel, DH and Nalesnik, MA and Nusbacher, J and Diliz-Pere, H and Hakala, TR (1984) Pancreaticoduodenal transplantation in humans. Surgery Gynecology and Obstetrics, 159 (3). 265 - 272. ISSN 0039-6087

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Whole cadaveric pancreata were transplanted to the pelvic extraperitoneal location in four patients with diabetes who previously had undergone successful cadaveric renal transplantation. One graft was lost within a few hours from venous thrombosis but with patient survival. The other three are providing normal endocrine function after two and a half, 11 and 12 months. The exocrine pancreatic secretions were drained into the recipient jejunum through enteric anastomoses. Because mucosal slough of the graft and duodenum and jejunum in two patients caused a protein losing enteropathy and necessitated reoperations, we now do the pancreatic transplantation with only a blister of graft duodenum large enough for side-to-side enteroenterostomy. The spleen has been transplanted with the pancreas mainly for technical reasons, and this technique should have further trials in spite of the fact that delayed graft splenectomy became necessary in two recipients to treat graft induced hematologic complications.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Iwatsuki, S
Shaw, BW
Greene, DA
Van Thiel, DH
Nalesnik, MAnalesnik@pitt.eduNALESNIK
Nusbacher, J
Diliz-Pere, H
Hakala, TR
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 25 October 1984
Date Type: Publication
Journal or Publication Title: Surgery Gynecology and Obstetrics
Volume: 159
Number: 3
Page Range: 265 - 272
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6087
Other ID: uls-drl:31735062115294, Starzl CV No. 568
Date Deposited: 08 Apr 2010 17:09
Last Modified: 23 Jan 2018 20:55


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