Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Pathology of hepatic transplantation. A review of 62 adult allograft recipients immunosuppressed with a cyclosporine/steroid regimen

Demetris, AJ and Lasky, S and van Thiel, DH and Starzl, TE and Dekker, A (1985) Pathology of hepatic transplantation. A review of 62 adult allograft recipients immunosuppressed with a cyclosporine/steroid regimen. American Journal of Pathology, 118 (1). 151 - 161. ISSN 0002-9440

[img]
Preview
PDF
Accepted Version
Available under License : See the attached license file.

Download (2MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

The pathologic specimens (n = 118) and hospital course pertinent to each of 62 adult liver allograft recipients were reviewed. Biopsies and retransplanted organs were obtained at the discretion of the surgical team on the basis of the postoperative clinical course (< 1 day to > 12 years after transplantation), and final interpretation of the pathologic material was based on a correlation of all available data. Most of the specimens (n = 85) were obtained within the first 2 months, and diagnoses in this time period included rejection, biliary obstruction/cholangitis, vascular injury, herpesvirus and cytomegalovirus hepatitis, graft necrosis, and functional cholestasis. Thereafter, rejection and recurrent or primary viral hepatitis were the major causes of graft dysfunction. Histologically, hepatic rejection is manifested by a cellular mediated injury of hepatocytes and bile ductules and a spectrum of vascular lesions in medium-sized hilar arteries. Morphologic changes of biliary duct obstruction and viral liver disease were at times difficult to differentiate from rejection. Two pretransplant disorders, type B viral hepatitis and the Budd-Chiari syndrome, recurred in grafted organs. Although interpretation of pathologic material may be difficult at times, it frequently is helpful in planning an approach to management of liver allograft recipients.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Demetris, AJ
Lasky, S
van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Dekker, A
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 10 April 1985
Date Type: Publication
Journal or Publication Title: American Journal of Pathology
Volume: 118
Number: 1
Page Range: 151 - 161
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0002-9440
Other ID: uls-drl:31735062115609, Starzl CV No. 593
Date Deposited: 08 Apr 2010 17:10
Last Modified: 27 Jan 2019 02:55
URI: http://d-scholarship.pitt.edu/id/eprint/3979

Metrics

Monthly Views for the past 3 years

Plum Analytics


Actions (login required)

View Item View Item