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The relation of preoperative coagulation findings to diagnosis, blood usage, and survival in adult liver transplantation

Bontempo, FA and Lewis, JH and Van Thiel, DH and Spero, JA and Ragni, MV and Butler, P and Israel, L and Starzl, TE (1985) The relation of preoperative coagulation findings to diagnosis, blood usage, and survival in adult liver transplantation. Transplantation, 39 (5). 532 - 536. ISSN 0041-1337

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Abstract

A group of 70 adults with end-stage liver disease received 87 homologous liver transplants from 7/11/81 and 7/11/83. The recipients fell into the following diagnostic categories: Postnecrotic cirrhosis (PNC) in 22, primary biliary cirrhosis (PBC) in 18, cancer or neoplasia (CA) in 11, sclerosing cholangitis (SC) in 8 and miscellaneous (MISC) in 11. Survival for six months or longer was 46%: Survival by group was PBC=67%, CA=55%, PNC=45%, SC=25%, and MISC=18%. Preoperative coagulation profiles were evaluated on 64 of the 70 first transplant patients by assigning a score derived from one point per abnormality in each of 8 tests. Mean coagulation abnormality scores (CAS) were strikingly elevated in the PNC and MISC groups. Mean intraoperative blood product usage was 43 units of RBCs, 40 units of fresh frozen plasma (FFP), 21 units of platelets, and 9 bags of cryoprecipitate. Direct correlations were found between CAS and RBC usage (+0.454, P=001), CAS, and survival of 6 months or longer (-0.281, P=.02), and RBC usage and survival (-0.408, P=.001). These findings indicate that the degree of coagulation abnormality and the type of liver disease may be predictive of intraoperative blood usage and survival in liver transplantation in adults. © 1985 by The Williams & Wilkins Co.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Bontempo, FA
Lewis, JH
Van Thiel, DH
Spero, JA
Ragni, MV
Butler, P
Israel, L
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1985
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 39
Number: 5
Page Range: 532 - 536
DOI or Unique Handle: 10.1097/00007890-198505000-00015
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062115591, Starzl CV No. 594
Date Deposited: 08 Apr 2010 17:10
Last Modified: 05 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/3980

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