Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: The role of primary infection

Ho, M and Miller, G and Atchison, RW and Breinig, MK and Dummer, JS and Andiman, W and Starzl, TE and Eastman, R and Griffith, BP and Hardesty, RL and Bahnson, HT and Hakala, TR and Rosenthal, JT (1985) Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: The role of primary infection. Journal of Infectious Diseases, 152 (5). 876 - 886. ISSN 0022-1899

[img]
Preview
PDF
Accepted Version
Available under License : See the attached license file.

Download (1MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Fourteen patients who developed B cell lymphomas or lymphoproliferative lesions after kidney, liver, heart, or heart-lung transplantation in Pittsburgh during 1981-1983 had active infection with Epstein-Barr virus (EBV)of the primary (six patients), reactivated (seven patients), or chronic (one patient) type. In transplant patients without tumors, the incidence of EBV infection was 30% (39 of 128). Only three of these patients had primary infections. Thus the frequency of active infection was significantly higher in patients with tumors, and patients with primary infections were at greater risk of developing tumors. Five of 13 tumors tested contained EBV nuclear antigen (EBNA) and nine of 11 contained EBV genomes detected by DNA-DNA hybridization with BamHI K, BamHI W, or EcoRI B cloned probes. All EBNA-positive tumors, except one, were also positive by hybridization. Only one tumor was negative for both EBNA and EBV DNA. These data suggest that EBV plays an etiologic role in the development of these lesions. © 1985 by The University of Chicago.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ho, Mmonto@pitt.eduMONTO
Miller, G
Atchison, RW
Breinig, MK
Dummer, JS
Andiman, W
Starzl, TEtes11@pitt.eduTES11
Eastman, R
Griffith, BP
Hardesty, RL
Bahnson, HT
Hakala, TR
Rosenthal, JT
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 November 1985
Date Type: Publication
Journal or Publication Title: Journal of Infectious Diseases
Volume: 152
Number: 5
Page Range: 876 - 886
DOI or Unique Handle: 10.1093/infdis/152.5.876
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-1899
Other ID: uls-drl:31735062115625, Starzl CV No. 599
Date Deposited: 08 Apr 2010 17:10
Last Modified: 13 Oct 2017 20:57
URI: http://d-scholarship.pitt.edu/id/eprint/3985

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item