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A Novel Predictive Model for Alzheimer’s Disease Using Multi-view Brain Networks

Wei, Qianhao (2021) A Novel Predictive Model for Alzheimer’s Disease Using Multi-view Brain Networks. Master's Thesis, University of Pittsburgh. (Unpublished)

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Alzheimer’s disease (AD) is an irreversible and progressive disease that begins with mild memory loss possibly leading to loss of the ability to respond to the environment. Diffusion-weighted magnetic resonance images (DW-MRI)-derived brain network has been widely used as an important tool to study AD. Many methods have been proposed to reconstruct brain structural networks in the literature. However, due to the variance of each method, the resulted brain networks are distinct. Consequently, the downstream analyses and results are varied, which significantly affect the clinical implications of the conclusions. Moreover, due to the limitation of the available imaging data, it may also be a challenge to effectively capture highly discriminative features related to AD, which can further affect the predictive model’s performance. In this thesis, we address these challenges by proposing a new CNN (Convolution Neural Network) and LSTM (Long Short-Term Memory) mixed model for AD classification. Here we treat different networks from the same subject as multi-view data and apply our new model on two independent publicly available AD cohorts (202 subjects from the 2nd stage of Alzheimer’s disease neuroimaging initiative or ADNI2 and 445 subjects from National Alzheimer’s Coordinating Center or NACC). ADNI2 has four group data (normal control or NC, early mild cognitive impairment or EMCI, late mild cognitive impairment or LMCI and AD) while NACC has only three group data (NC, MCI, and AD). Our experimental results show that our new model can achieve around 96% accuracy for multi-group classifications for both cohorts, significantly outperformed those baseline methods whose accuracy is around 75%.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Wei, Qianhaoqiw65@pitt.eduqiw65
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairZhan,
Committee MemberHu,
Committee MemberXiong,
Date: 13 June 2021
Date Type: Publication
Defense Date: 8 December 2020
Approval Date: 13 June 2021
Submission Date: 7 January 2021
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 30
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Electrical and Computer Engineering
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Alzheimer’s disease; convolutional neural network; classification;
Related URLs:
Date Deposited: 13 Jun 2021 18:42
Last Modified: 13 Jun 2021 18:42


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