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Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation

Kang, YG and Martin, DJ and Marquez, J and Lewis, JH and Bontempo, FA and Shaw, BW and Starzl, TE and Winter, PM (1985) Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation. Anesthesia and Analgesia, 64 (9). 888 - 896. ISSN 0003-2999

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Abstract

The blood coagulation system of 66 consecutive patients undergoing consecutive liver transplantations was monitored by thrombelastograph and analytic coagulation profile. A poor preoperative coagulation state, decrease in levels of coagulation factors, progressive fibrinolysis, and whole blood clot lysis were observed during the preanhepatic and anhepatic stages of surgery. A further general decrease in coagulation factors and platelets, activation of fibrinolysis, and abrupt decrease in levels of factors V and VIII occurred before and with reperfusion of the homograft. Recovery of blood coagulability began 30-60 min after reperfusion of the graft liver, and coagulability had returned toward baseline values 2 hr after reperfusion. A positive correlation was shown between the variables of thrombelastography and those of the coagulation profile. Thrombelastography was shown to be a reliable and rapid monitoring system. Its use was associated with a 33% reduction of blood and fluid infusion volume, whereas blood coagulability was maintained without an increase in the number of blood product donors.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kang, YG
Martin, DJ
Marquez, J
Lewis, JH
Bontempo, FA
Shaw, BW
Starzl, TEtes11@pitt.eduTES11
Winter, PM
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 13 November 1985
Date Type: Publication
Journal or Publication Title: Anesthesia and Analgesia
Volume: 64
Number: 9
Page Range: 888 - 896
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0003-2999
Other ID: uls-drl:31735062115682, Starzl CV No. 601
Date Deposited: 08 Apr 2010 17:10
Last Modified: 13 Oct 2017 20:56
URI: http://d-scholarship.pitt.edu/id/eprint/3987

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