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Multi-Foci Beamforming Using Curved Linear Array Transducer for Qualitative Identification of Lipids in Human Liver

Khalid, Waqas (2021) Multi-Foci Beamforming Using Curved Linear Array Transducer for Qualitative Identification of Lipids in Human Liver. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver chronic diseases in the U.S. and its prevalence is growing in the world. In the United States, it affects an estimate of 80 to 100 million people. In less than a decade, NAFLD will likely become the number one cause of liver transplants in the country. NAFLD cases have risen rapidly over the last three decades and is the most common liver disease in children. NAFLD encompasses a disease spectrum of a variety of liver conditions ranging from simple steatosis (SS) to nonalcoholic steatohepatitis (NASH). SS is a benign form of the disease, characterized by the accumulation of lipid in the liver. On the other hand, NASH is defined by hepatic steatosis with cell injury, hepatic ballooning and various degrees of fibrosis. NASH may further develop into cirrhosis, liver failure and hepatocellular carcinoma (HCC). A non-invasive, early detection and accurate staging of NAFLD may allow for a timely intervention and treatment to prevent the progression of the disease to cirrhosis and HCC.
We hypothesized a new dual-modality ultrasound imaging combining acoustic radiation force impulse (ARFI) imaging and thermal strain imaging (TSI) implemented on a clinical ultrasound probe. ARFI imaging utilizes high intensity focused ultrasound to generate a push in a region of interest (ROI). The response of the tissue inside the region of excitation due to the acoustic radiation push is determined by estimating the displacement between the pre-push reference frames and the post-push tracking frames. TSI has been used in the field of medical imaging for detecting lipids in atherosclerotic plaques and quantification of liver fat in ob/ob mice. TSI is based on the fact that the speed of sound changes differently in respect to the increase in temperature for different tissue composition. Lipids register a decreasing sound speed with increasing temperature, whereas water-bearing tissue exhibit an increasing sound speed with increasing temperature. Development of the proposed multi-modality system will be a step towards a novel clinical system which would permit the creation of a single co-registered image featuring information regarding lipid content and liver stiffness.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Khalid, Waqaswbk6@pitt.eduwbk6
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairKim, Kangkangkim@pitt.edukangkim
Committee MemberLaymon, Charlescml14@pitt.educml14
Committee MemberStetten, Georgestetten@pitt.edustetten
Committee MemberChen, Xucaixuc4@pitt.eduxuc4
Date: 26 January 2021
Date Type: Publication
Defense Date: 15 September 2020
Approval Date: 26 January 2021
Submission Date: 15 November 2020
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 134
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Bioengineering
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: NAFLD, Multi-foci beamforming
Date Deposited: 26 Jan 2021 21:36
Last Modified: 26 Jan 2021 21:36


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