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Induction of DR\IA antigens in human liver allografts: An immunocytochemical and clinicopathologic analysis of twenty failed grafts

Demetris, AJ and Lasky, S and Van Thiel, DH and Starzl, TE and Whiteside, T (1985) Induction of DR\IA antigens in human liver allografts: An immunocytochemical and clinicopathologic analysis of twenty failed grafts. Transplantation, 40 (5). 504 - 509. ISSN 0041-1337

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Abstract

Twenty failed human liver allograft specimens obtained at the time of retransplantation procedures were studied using a panel of monoclonal antibodies (T11, T4, T8, NK, B1, OKM1, OKM5, Ia, DR). A clinicopathologic analysis was used to distinguish between graft failures secondary to rejection (n=10) and those due, at least in part, to other causes (n=10). T lymphocytes constituted the major infiltrating cellular population in the liver in rejection cases, but significant numbers of B cells and monocytes/macrophages were present also. Following transplantation, but not before, the bile duct epithelium, as well as portal and central vein and hepatic artery endothelium expressed DR/Ia antigens. These structures are preferential targets of the rejection reaction. The selective destruction of bile ducts in livers undergoing rejection was manifested in these patients by striking elevations of serum gamma glutamyl transpeptidase (GGTP) activity, a marker of biliary epithelial damage. The induced expression of DR/Ia antigens on structures targeted for immune destruction may be an important event in the pathogenesis of liver allograft rejection. © 1985 by The Williams and Wilkins Co.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Demetris, AJ
Lasky, S
Van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Whiteside, T
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1985
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 40
Number: 5
Page Range: 504 - 509
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062115732, Starzl CV No. 612
Date Deposited: 08 Apr 2010 17:10
Last Modified: 13 Oct 2017 21:57
URI: http://d-scholarship.pitt.edu/id/eprint/3998

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