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Role of liver transplantation in cancer therapy

Iwatsuki, S and Gordon, RD and Shaw, BW and Starzl, TE (1985) Role of liver transplantation in cancer therapy. Annals of Surgery, 202 (4). 401 - 407. ISSN 0003-4932

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Fifty-four patients underwent total hepatectomy and liver replacement in the presence of a primary liver malignancy. in 13 recipients in whom the hepatic tumors were incidental to some other endstage liver disease, recurrence was not seen and 12 of the 13 patients are alive after 4 months to 15 1/2 years. In contrast, tumors recurred in 3 of every 4 patients who received liver replacement primarily because of hepatic malignancies that could not be resected by conventional techniques of subtotal hepatectomy and who lived for at least 2 months after transplantation. The most encouraging results were in patients with the fibrolamellar hepatocellular carcinomas that grow slowly and metastasize late, but even with this lesion, the recurrence rate was 57%. In future trials, additional effective anticancer therapy will be needed to improve the results of liver transplantation for primary liver malignancy, but what an improved strategy should be has not yet been defined.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Iwatsuki, S
Gordon, RD
Shaw, BW
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1985
Date Type: Publication
Journal or Publication Title: Annals of Surgery
Volume: 202
Number: 4
Page Range: 401 - 407
DOI or Unique Handle: 10.1097/00000658-198510000-00001
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0003-4932
Other ID: uls-drl:31735062115831, Starzl CV No. 618
Date Deposited: 08 Apr 2010 17:10
Last Modified: 02 Feb 2019 13:55


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