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Immunosuppression and other nonsurgical factors in the improved results of liver transplantation.

Starzl, TE and Iwatsuki, S and Shaw, BW and Gordon, RD and Esquivel, CO (1985) Immunosuppression and other nonsurgical factors in the improved results of liver transplantation. Seminars in liver disease, 5 (4). 334 - 343. ISSN 0272-8087

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Abstract

During the last 5 years, liver transplantation has become a service as opposed to an experimental operation. The most important factor in making this possible has been the introduction of cyclosporine-steroid therapy. At the same time, liver transplantation has been made more practical by improvements in diagnosing and managing other causes of postoperative hepatic dysfunction. Tissue typing and matching have played no role in improving the results of liver transplantation. With the demonstration that performed antibody states are irrelevant, even avoidance of positive cross-matches caused by cytotoxic antibodies and observance of ABO blood group barriers have become unnecessary if the recipient's needs are great. With the exceptions of malignancy and cirrhosis, the nature of the underlying hepatic disease has not profoundly influenced the results. Retransplantation has played an important role in improving survival, although the costs of retransplantation have been extremely high.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Iwatsuki, S
Shaw, BW
Gordon, RD
Esquivel, CO
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1985
Date Type: Publication
Journal or Publication Title: Seminars in liver disease
Volume: 5
Number: 4
Page Range: 334 - 343
DOI or Unique Handle: 10.1055/s-2008-1040630
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0272-8087
Article Type: Review
Other ID: uls-drl:31735062115898, Starzl CV No. 628
Date Deposited: 08 Apr 2010 17:10
Last Modified: 02 Feb 2019 13:57
URI: http://d-scholarship.pitt.edu/id/eprint/4014

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