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The Effect of Weight Reduction Interventions on Health-Related Quality of Life Among Overweight/Obese Individuals

MITCHELL-MILAND, CHANTELE (2021) The Effect of Weight Reduction Interventions on Health-Related Quality of Life Among Overweight/Obese Individuals. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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INTRODUCTION: Health related quality of life (HRQoL) has been shown to improve after participation in two effective lifestyle interventions to treat overweight/obesity, a Lifestyle Intervention (increased physical activity and weight loss – and bariatric surgery (surgically altering the stomach and/or intestines). It is unknown if HRQoL (measured by Euroqol 5 dimension – EQ5D) is maintained over long periods of time or if HRQoL also improves when the lifestyle intervention movement goal focuses on sedentary behavior reduction.
METHODS: This dissertation first examined how HRQoL (EQ5D index and EQVAS – visual analog scale) improved among participants enrolled in a 12-month DPP-based community lifestyle intervention program of lifestyle change vs. change in sedentary behavior. at 6 months, and among each intervention group prepost (6 and 12 months). Second, this paper evaluated changes in HRQoL among a cohort of participants enrolled in the Longitudinal Assessment of Bariatric Study (LABS-2). One assessment evaluated changes in HRQoL among who underwent the Roux-En-Y Gastric Bypass or Laparoscopic Band Gastric Bypass up to 5 years postsurgery. Another assessment evaluated HRQoL measurement among 2 instruments presurgery and 1-year postsurgery (EQ5D and Short-Form 6 dimension – SF6D derived from the SF36).
RESULTS: Components of HRQoL improved significantly in both the lifestyle and sedentary intervention groups compared to the delayed control group at 6 months and prepost at 6 months and 12 months. Among LABS-2 participants, improvements in HRQoL were sustained over 5 years in both types of surgery groups. Results also demonstrated that changes in HRQoL differed by instrument (EQ5D or SF6D) where the EQ5D had more ceiling effects (responses at the highest point of the instrument).
PUBLIC HEALTH SIGNIFICANCE: Participation in community lifestyle interventions with a sedentary behavior goal improved HRQoL providing an alternate effective intervention strategy for those who can’t or won’t engage in moderate physical activity and improvements in HRQoL were sustained up to 5 years after bariatric surgery. The EQ5D and SF6D provided different assessments of HRQoL among bariatric patients which may impact systematic reviews and interpretations of how bariatric surgery affects quality of life.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
MITCHELL-MILAND, CHANTELEcem54@pitt.educem54
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairSonger, Thomastjs@pitt.eduTJS
Committee MemberRockette-Wagner, BonnyBJR26@pitt.eduBJR26
Committee MemberGary-Webb, Tiffanytgary@pitt.edutgary
Committee MemberKriska, AndreaKriskaA@edc.pitt.eduAKY
Committee MemberYouk, Ada O.ayouk@pitt.eduAYOUK
Committee MemberKing, WendyKingW@edc.pitt.eduKingW
Date: 19 January 2021
Date Type: Publication
Defense Date: 10 November 2020
Approval Date: 19 January 2021
Submission Date: 8 January 2021
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 164
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Obesity, lifestyle intervention, bariatric surgery, health related quality of life
Date Deposited: 19 Jan 2021 20:07
Last Modified: 19 Jan 2023 06:15


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