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Innate Immunity to Mucosal Candida Infections

Verma, Akash and Gaffen, Sarah and Swidergall, Marc (2017) Innate Immunity to Mucosal Candida Infections. Journal of Fungi, 3 (4). ISSN 2309-608X

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Abstract

Mucosal epithelial tissues are exposed to high numbers of microbes, including commensal fungi, and are able to distinguish between those that are avirulent and those that cause disease. Epithelial cells have evolved multiple mechanisms to defend against colonization and invasion by Candida species. The interplay between mucosal epithelial tissues and immune cells is key for control and clearance of fungal infections. Our understanding of the mucosal innate host defense system has expanded recently with new studies bringing to light the importance of epithelial cell responses, innate T cells, neutrophils, and other phagocytes during Candida infections. Epithelial tissues release cytokines, host defense peptides, and alarmins during Candida invasion that act in concert to limit fungal proliferation and recruit immune effector cells. The innate T cell/IL-17 axis and recruitment of neutrophils are of central importance in controlling mucosal fungal infections. Here, we review current knowledge of the innate immunity at sites of mucosal Candida infection, with a focus on infections caused by C. albicans.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Verma, Akash
Gaffen, Sarahsarah.gaffen@pitt.edu
Swidergall, Marc
Date: 31 October 2017
Date Type: Publication
Journal or Publication Title: Journal of Fungi
Volume: 3
Number: 4
Publisher: MDPI AG
DOI or Unique Handle: 10.3390/jof3040060
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Uncontrolled Keywords: oropharyngeal candidiasis, vulvovaginal candidiasis, epithelial cells, antimicrobial peptides, alarmins, IL-17, innate T cells, antifungal immunity
ISSN: 2309-608X
Official URL: http://dx.doi.org/10.3390/jof3040060
Funders: National Institute of Dental and Craniofacial Research of the National Institutes of Health, National Institutes of Health
Article Type: Review
Date Deposited: 11 Jan 2021 23:21
Last Modified: 11 Jan 2021 23:21
URI: http://d-scholarship.pitt.edu/id/eprint/40159

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