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T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models

Watson, Alan and Klimstra, William (2017) T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models. Viruses, 9 (4). ISSN 1999-4915

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The 17D line of yellow fever virus vaccines is among the most effective vaccines ever created. The humoral and cellular immunity elicited by 17D has been well characterized in humans. Neutralizing antibodies have long been known to provide protection against challenge with a wild-type virus. However, a well characterized T cell immune response that is robust, long-lived and polyfunctional is also elicited by 17D. It remains unclear whether this arm of immunity is protective following challenge with a wild-type virus. Here we introduce the 17D line of yellow fever virus vaccines, describe the current state of knowledge regarding the immunity directed towards the vaccines in humans and conclude with a discussion of animal models that are useful for evaluating T cell-mediated immune protection to yellow fever virus.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Watson, AlanAlan.Watson@pitt.eduAlan.Watson
Klimstra, Williamklimstra@pitt.eduklimstra
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 11 April 2017
Date Type: Publication
Journal or Publication Title: Viruses
Volume: 9
Number: 4
Publisher: MDPI AG
DOI or Unique Handle: 10.3390/v9040077
Schools and Programs: School of Medicine > Microbiology and Molecular Genetics
Refereed: Yes
Uncontrolled Keywords: yellow fever virus; YFV; flavivirus; 17D; 17DD; 17D-204; T cell; vaccine; animal models; dengue; West Nile; Zika; live attenuated vaccine; chimerivax; vaccine development
ISSN: 1999-4915
Official URL:
Article Type: Review
Date Deposited: 02 Feb 2021 19:36
Last Modified: 02 Feb 2021 19:36


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