Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Emerging Metabolic Therapies in Pulmonary Arterial Hypertension

Harvey, Lloyd and Chan, Stephen (2017) Emerging Metabolic Therapies in Pulmonary Arterial Hypertension. Journal of Clinical Medicine, 6 (4). ISSN 2077-0383

Published Version

Download (1MB) | Preview


Pulmonary hypertension (PH) is an enigmatic vascular disorder characterized by pulmonary vascular remodeling and increased pulmonary vascular resistance, ultimately resulting in pressure overload, dysfunction, and failure of the right ventricle. Current medications for PH do not reverse or prevent disease progression, and current diagnostic strategies are suboptimal for detecting early-stage disease. Thus, there is a substantial need to develop new diagnostics and therapies that target the molecular origins of PH. Emerging investigations have defined metabolic aberrations as fundamental and early components of disease manifestation in both pulmonary vasculature and the right ventricle. As such, the elucidation of metabolic dysregulation in pulmonary hypertension allows for greater therapeutic insight into preventing, halting, or even reversing disease progression. This review will aim to discuss (1) the reprogramming and dysregulation of metabolic pathways in pulmonary hypertension; (2) the emerging therapeutic interventions targeting these metabolic pathways; and (3) further innovation needed to overcome barriers in the treatment of this devastating disease.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Centers: Other Centers, Institutes, Offices, or Units > Vascular Medicine Institute
Date: 4 April 2017
Date Type: Publication
Journal or Publication Title: Journal of Clinical Medicine
Volume: 6
Number: 4
Publisher: MDPI AG
DOI or Unique Handle: 10.3390/jcm6040043
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Uncontrolled Keywords: pulmonary arterial hypertension, metabolism, metabolic reprogramming, hypoxia-inducible factor, therapeutics
ISSN: 2077-0383
Official URL:
Funders: NIH Medical Scientist Training Program, NIH, American Heart Association
Article Type: Review
Date Deposited: 02 Feb 2021 19:40
Last Modified: 02 Feb 2021 19:40


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item