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TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action

Du, Wenwen and Yang, Min and Turner, Abbey and Xu, Chunling and Ferris, Robert and Huang, Jianan and Kane, Lawrence and Lu, Binfeng (2017) TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action. International Journal of Molecular Sciences, 18 (3). ISSN 1422-0067

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Cancer immunotherapy has produced impressive clinical results in recent years. Despite the success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death receptor 1 (PD-1), a large portion of cancer patients have not yet benefited from this novel therapy. T cell immunoglobulin and mucin domain 3 (TIM-3) has been shown to mediate immune tolerance in mouse models of infectious diseases, alloimmunity, autoimmunity, and tumor Immunity. Thus, targeting TIM-3 emerges as a promising approach for further improvement of current immunotherapy. Despite a large amount of experimental data showing an immune suppressive function of TIM-3 in vivo, the exact mechanisms are not well understood. To enable effective targeting of TIM-3 for tumor immunotherapy, further in-depth mechanistic studies are warranted. These studies will also provide much-needed insight for the rational design of novel combination therapy with other checkpoint blockers. In this review, we summarize key evidence supporting an immune regulatory role of TIM-3 and discuss possible mechanisms of action.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Du, Wenwen
Yang, Min
Turner, Abbey
Xu, Chunling
Huang, Jianan
Kane, Lawrencelkane@pitt.edulkane
Lu, Binfengbinfeng@pitt.edubinfeng
Date: 16 March 2017
Date Type: Publication
Journal or Publication Title: International Journal of Molecular Sciences
Volume: 18
Number: 3
Publisher: MDPI AG
DOI or Unique Handle: 10.3390/ijms18030645
Schools and Programs: School of Medicine > Immunology
Refereed: Yes
Uncontrolled Keywords: TIM-3, T cell subsets, tumor microenvironment, antitumor immune responses
ISSN: 1422-0067
Official URL:
Funders: Head and Neck Cancer Spore Development award, Roswell Park Cancer Institute/University of Pittsburgh Cancer Institute Ovarian Cancer Specialized Programs of Research Excellence, National Natural Science Foundation of China
Article Type: Research Article
Date Deposited: 04 Feb 2021 18:13
Last Modified: 04 Feb 2021 18:13


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