Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets

Li, Jihong and Uzal, Francisco and McClane, Bruce (2016) Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets. Toxins, 8 (11). ISSN 2072-6651

[img]
Preview
PDF
Published Version

Download (1MB) | Preview

Abstract

Clostridium perfringens is a major cause of histotoxic and intestinal infections of humans and other animals. This Gram-positive anaerobic bacterium can produce up to three sialidases named NanH, NanI, and NanJ. The role of sialidases in histotoxic infections, such as gas gangrene (clostridial myonecrosis), remains equivocal. However, recent in vitro studies suggest that NanI may contribute to intestinal virulence by upregulating production of some toxins associated with intestinal infection, increasing the binding and activity of some of those toxins, and enhancing adherence of C. perfringens to intestinal cells. Possible contributions of NanI to intestinal colonization are further supported by observations that the C. perfringens strains causing acute food poisoning in humans often lack the nanI gene, while other C. perfringens strains causing chronic intestinal infections in humans usually carry a nanI gene. Certain sialidase inhibitors have been shown to block NanI activity and reduce C. perfringens adherence to cultured enterocyte-like cells, opening the possibility that sialidase inhibitors could be useful therapeutics against C. perfringens intestinal infections. These initial in vitro observations should be tested for their in vivo significance using animal models of intestinal infections.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Li, Jihongjihongli@pitt.edujihongli
Uzal, Francisco
McClane, Brucebamcc@pitt.edubamcc
Date: 19 November 2016
Date Type: Publication
Journal or Publication Title: Toxins
Volume: 8
Number: 11
Publisher: MDPI AG
DOI or Unique Handle: 10.3390/toxins8110341
Schools and Programs: School of Medicine > Microbiology and Molecular Genetics
Refereed: Yes
Uncontrolled Keywords: Clostridium perfringens, intestinal infections, gas gangrene, toxins, sialidases, sialidase inhibitors
ISSN: 2072-6651
Official URL: http://dx.doi.org/10.3390/toxins8110341
Funders: National Institute of Allergy and Infectious Disease
Article Type: Review
Date Deposited: 04 Feb 2021 18:08
Last Modified: 04 Feb 2021 18:08
URI: http://d-scholarship.pitt.edu/id/eprint/40226

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item