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Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets

Li, Jihong and Uzal, Francisco and McClane, Bruce (2016) Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets. Toxins, 8 (11). ISSN 2072-6651

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Clostridium perfringens is a major cause of histotoxic and intestinal infections of humans and other animals. This Gram-positive anaerobic bacterium can produce up to three sialidases named NanH, NanI, and NanJ. The role of sialidases in histotoxic infections, such as gas gangrene (clostridial myonecrosis), remains equivocal. However, recent in vitro studies suggest that NanI may contribute to intestinal virulence by upregulating production of some toxins associated with intestinal infection, increasing the binding and activity of some of those toxins, and enhancing adherence of C. perfringens to intestinal cells. Possible contributions of NanI to intestinal colonization are further supported by observations that the C. perfringens strains causing acute food poisoning in humans often lack the nanI gene, while other C. perfringens strains causing chronic intestinal infections in humans usually carry a nanI gene. Certain sialidase inhibitors have been shown to block NanI activity and reduce C. perfringens adherence to cultured enterocyte-like cells, opening the possibility that sialidase inhibitors could be useful therapeutics against C. perfringens intestinal infections. These initial in vitro observations should be tested for their in vivo significance using animal models of intestinal infections.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Li, Jihongjihongli@pitt.edujihongli
Uzal, Francisco
McClane, Brucebamcc@pitt.edubamcc
Date: 19 November 2016
Date Type: Publication
Journal or Publication Title: Toxins
Volume: 8
Number: 11
Publisher: MDPI AG
DOI or Unique Handle: 10.3390/toxins8110341
Schools and Programs: School of Medicine > Microbiology and Molecular Genetics
Refereed: Yes
Uncontrolled Keywords: Clostridium perfringens, intestinal infections, gas gangrene, toxins, sialidases, sialidase inhibitors
ISSN: 2072-6651
Official URL:
Funders: National Institute of Allergy and Infectious Disease
Article Type: Review
Date Deposited: 04 Feb 2021 18:08
Last Modified: 04 Feb 2021 18:08


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