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Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis

Chiu, Bin and Tai, Huai-Ching and Chung, Shiu-Dong and Birder, Lori (2016) Botulinum Toxin A for Bladder Pain Syndrome/Interstitial Cystitis. Toxins, 8 (7). ISSN 2072-6651

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Botulinum neurotoxin A (BoNT-A), derived from Clostridium botulinum, has been used clinically for several diseases or syndrome including chronic migraine, spasticity, focal dystonia and other neuropathic pain. Chronic pelvic or bladder pain is the one of the core symptoms of bladder pain syndrome/interstitial cystitis (BPS/IC). However, in the field of urology, chronic bladder or pelvic pain is often difficult to eradicate by oral medications or bladder instillation therapy. We are looking for new treatment modality to improve bladder pain or associated urinary symptoms such as frequency and urgency for patients with BPS/IC. Recent studies investigating the mechanism of the antinociceptive effects of BoNT A suggest that it can inhibit the release of peripheral neurotransmitters and inflammatory mediators from sensory nerves. In this review, we will examine the evidence supporting the use of BoNTs in bladder pain from basic science models and review the clinical studies on therapeutic applications of BoNT for BPS/IC.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Chiu, Bin
Tai, Huai-Ching
Chung, Shiu-Dong
Birder, Lorilbirder@pitt.edulbirder
Date: 1 July 2016
Date Type: Publication
Journal or Publication Title: Toxins
Volume: 8
Number: 7
Publisher: MDPI AG
DOI or Unique Handle: 10.3390/toxins8070201
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Uncontrolled Keywords: cystitis, botulinum toxin A, interstitial cystitis, intravesical injection
ISSN: 2072-6651
Official URL:
Article Type: Review
Date Deposited: 04 Feb 2021 21:28
Last Modified: 04 Feb 2021 21:28


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