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Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks

Zhang, Jingyu and Tian, Xiao-Jun and Xing, Jianhua (2016) Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks. Journal of Clinical Medicine, 5 (4). ISSN 2077-0383

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Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing, and cancer development. It involves cooperation of signaling pathways, such as transformation growth factor-β (TGF-β), Sonic Hedgehog (SHH), and WNT pathways. These signaling pathways crosstalk to each other and converge to key transcription factors (e.g., SNAIL1) to initialize and maintain the process of EMT. The functional roles of multi-signaling pathway crosstalks in EMT are sophisticated and, thus, remain to be explored. In this review, we focused on three major signal transduction pathways that promote or regulate EMT in carcinoma. We discussed the network structures, and provided a brief overview of the current therapy strategies and drug development targeted to these three signal transduction pathways. Finally, we highlighted systems biology approaches that can accelerate the process of deconstructing complex networks and drug discovery.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Zhang, Jingyu
Tian, Xiao-Jun
Xing, Jianhuaxing1@pitt.eduxing1
Date: 28 March 2016
Date Type: Publication
Journal or Publication Title: Journal of Clinical Medicine
Volume: 5
Number: 4
Publisher: MDPI AG
DOI or Unique Handle: 10.3390/jcm5040041
Schools and Programs: School of Medicine > Computational and Systems Biology
Refereed: Yes
Uncontrolled Keywords: signaling transduction pathways, EMT, TGF-β, SHH, WNT, modeling
ISSN: 2077-0383
Official URL:
Funders: NIGMS-DMS joint mathematical biology program, PA Department of Health
Article Type: Review
Date Deposited: 04 Feb 2021 21:27
Last Modified: 04 Feb 2021 21:27


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