Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Determining gene expression control during neural differentiation through coupled protein localization and RNA-seq in single cells

Hainer, Sarah (2021) Determining gene expression control during neural differentiation through coupled protein localization and RNA-seq in single cells. In: Pitt Momentum Fund 2021.

[img]
Preview
PDF (Showcase Poster)
Updated Version

Download (291kB) | Preview

Abstract

Although the primary sequence of the eukaryotic genome is largely invariant across cells in an organism, the expression of genes is tightly regulated: specific complements and levels of expressed genes define the identity and function of cells. A primary mechanism of gene expression control is at the level of access to DNA sequences that can direct expression of individual genes. Access to these DNA regulatory elements is established and maintained by the combinatorial binding of an immense repertoire of transcription factors (TFs) and chromatin regulators which function together to drive cell-type-specific gene expression. There is a range of cell heterogeneity that enables distinct expression levels within a tissue or population of cells, establishing average expression within the population but conferring different properties on individual cells. Importantly, the level of gene expression heterogeneity across single cells has only recently become clear through technological innovations that have permitted the development of single-cell genomic assays.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Conference or Workshop Item (Poster)
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hainer, SarahSHAINER@pitt.edushainer0000-0003-0503-1183
Centers: Other Centers, Institutes, Offices, or Units > Office of Sponsored Research > Pitt Momentum Fund
Date: 2021
Event Title: Pitt Momentum Fund 2021
Event Type: Other
DOI or Unique Handle: 10.18117/qzqa-rp34
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: No
Date Deposited: 26 Mar 2021 19:10
Last Modified: 01 Sep 2021 11:28
URI: http://d-scholarship.pitt.edu/id/eprint/40353

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item