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Canine liver transplantation under nva cyclosporine versus cyclosporine

Todo, S and Porter, KA and Kam, I and Lynch, S and Venkataramanan, R and DeWolf, A and Starzl, TE (1986) Canine liver transplantation under nva cyclosporine versus cyclosporine. Transplantation, 41 (3). 296 - 300. ISSN 0041-1337

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Abstract

The immunosuppressive qualities and other features of a new cyclosporine (CsA) analogue, Nva < sup > 2 < /sup > -cyclosporine (Nva < sup > 2 < /sup > -CsA) were examined using canine orthotopic liver allografts. The mean survival time was 11.8±9.6 (SD) days in dogs without treatment, 60.8±34.4 days with Nva < sup > 2 < /sup > -CsA and 65.1±33.0 days with CsA. Functional abnormalities indicating toxic side effects were not noted either with Nva < sup > 2 < /sup > -CsA or with CsA. Using the same oral dose, the rate of blood level rise and the amount of the rise were greater with Nva < sup > 2 < /sup > -CsA. Histopathologically, Nva < sup > 2 < /sup > -CsA the treatment was associated with the same degree of hydropic vocuolation in the pars recta of the proximal tubules as CsA treatment. Thus, in the dog, Nva < sup > 2 < /sup > -CsA had identical immunosuppressive properties as CsA, with no functionally detectable toxicity affecting the liver and kidney. © 1986 by The Williams & Wilkins Co.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Todo, S
Porter, KA
Kam, I
Lynch, S
Venkataramanan, Rrv@pitt.eduRV
DeWolf, A
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1986
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 41
Number: 3
Page Range: 296 - 300
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062116284, Starzl CV No. 663
Date Deposited: 08 Apr 2010 17:11
Last Modified: 14 Oct 2017 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/4049

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