Todo, S and Porter, KA and Kam, I and Lynch, S and Venkataramanan, R and DeWolf, A and Starzl, TE
(1986)
Canine liver transplantation under nva cyclosporine versus cyclosporine.
Transplantation, 41 (3).
296 - 300.
ISSN 0041-1337
Abstract
The immunosuppressive qualities and other features of a new cyclosporine (CsA) analogue, Nva 2-cyclosporine (Nva 2-CsA) were examined using canine orthotopic liver allografts. The mean survival time was 11.8±9.6 (SD) days in dogs without treatment, 60.8±34.4 days with Nva 2-CsA and 65.1±33.0 days with CsA. Functional abnormalities indicating toxic side effects were not noted either with Nva 2-CsA or with CsA. Using the same oral dose, the rate of blood level rise and the amount of the rise were greater with Nva2-CsA. Histopathologically, Nva2-CsA the treatment was associated with the same degree of hydropic vocuolation in the pars recta of the proximal tubules as CsA treatment. Thus, in the dog, Nva2-CsA had identical immunosuppressive properties as CsA, with no functionally detectable toxicity affecting the liver and kidney. © 1986 by The Williams & Wilkins Co.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID |
---|
Todo, S | | | | Porter, KA | | | | Kam, I | | | | Lynch, S | | | | Venkataramanan, R | rv@pitt.edu | RV | | DeWolf, A | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1 January 1986 |
Date Type: |
Publication |
Journal or Publication Title: |
Transplantation |
Volume: |
41 |
Number: |
3 |
Page Range: |
296 - 300 |
DOI or Unique Handle: |
10.1097/00007890-198603000-00004 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0041-1337 |
Other ID: |
uls-drl:31735062116284, Starzl CV No. 663 |
Date Deposited: |
08 Apr 2010 17:11 |
Last Modified: |
22 Jun 2021 10:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/4049 |
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