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Canine liver transplantation under nva cyclosporine versus cyclosporine

Todo, S and Porter, KA and Kam, I and Lynch, S and Venkataramanan, R and DeWolf, A and Starzl, TE (1986) Canine liver transplantation under nva cyclosporine versus cyclosporine. Transplantation, 41 (3). 296 - 300. ISSN 0041-1337

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The immunosuppressive qualities and other features of a new cyclosporine (CsA) analogue, Nva 2-cyclosporine (Nva 2-CsA) were examined using canine orthotopic liver allografts. The mean survival time was 11.8±9.6 (SD) days in dogs without treatment, 60.8±34.4 days with Nva 2-CsA and 65.1±33.0 days with CsA. Functional abnormalities indicating toxic side effects were not noted either with Nva 2-CsA or with CsA. Using the same oral dose, the rate of blood level rise and the amount of the rise were greater with Nva2-CsA. Histopathologically, Nva2-CsA the treatment was associated with the same degree of hydropic vocuolation in the pars recta of the proximal tubules as CsA treatment. Thus, in the dog, Nva2-CsA had identical immunosuppressive properties as CsA, with no functionally detectable toxicity affecting the liver and kidney. © 1986 by The Williams & Wilkins Co.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Todo, S
Porter, KA
Kam, I
Lynch, S
Venkataramanan, Rrv@pitt.eduRV
DeWolf, A
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1986
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 41
Number: 3
Page Range: 296 - 300
DOI or Unique Handle: 10.1097/00007890-198603000-00004
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062116284, Starzl CV No. 663
Date Deposited: 08 Apr 2010 17:11
Last Modified: 22 Jun 2021 10:55


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