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Circadian rhythm of hepatic cytosolic and nuclear estrogen and androgen receptors

Francavilla, A and Eagon, PK and DiLeo, A and Van Thiel, DH and Panella, C and Polimeno, L and Amoruso, C and Ingrosso, M and Aquilino, AM and Starzl, TE (1986) Circadian rhythm of hepatic cytosolic and nuclear estrogen and androgen receptors. Gastroenterology, 91 (1). 182 - 188. ISSN 0016-5085

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Mammalian liver is a sex steroid-responsive tissue. The effects of these hormones presumably are mediated by hepatic estrogen receptors (ER) and androgen receptors (AR). Serum levels of sex hormones display circadian rhythms. Further, estrogens and androgens are commonly administered; administration of these agents is associated frequently with liver disease. Therefore, we investigated whether the cytosolic and nuclear sex steroid receptors also display a similar circadian rhythm, and whether variations occurred in the distribution of receptors between cytosolic and nuclear compartments. Animals were killed every 4 h from midnight till the following midnight; cytosolic and nuclear levels of both ER and AR were measured. Cytosolic ER reached a maximum level at 4 am, and a minimum at 8 pm and midnight of both days. Nuclear ER was highest at 8 am and lowest at 4 pm and 8 pm, a pattern which parallels variations in serum estradiol levels. Cytosolic AR was highest at 8 pm and lowest at midnight and 4 am. Nuclear AR was highest at 4 am and lowest at 4 pm and 8 pm. The highest level of nuclear AR does not correspond to the maximum serum testosterone level, which occurred at 4 pm. The total hepatic content of both ER and AR was not constant over the 24-h period, but varied considerably with time of day. These studies suggest that both ER and AR show a distinct circadian rhythm in subcellular compartmentalization, and that total hepatic content of ER and AR varies significantly during a 24-h period. © 1986.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Francavilla, A
Eagon, PK
DiLeo, A
Van Thiel, DH
Panella, C
Polimeno, L
Amoruso, C
Ingrosso, M
Aquilino, AM
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1986
Date Type: Publication
Journal or Publication Title: Gastroenterology
Volume: 91
Number: 1
Page Range: 182 - 188
DOI or Unique Handle: 10.1016/0016-5085(86)90456-7
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0016-5085
Other ID: uls-drl:31735062116334, Starzl CV No. 672
Date Deposited: 08 Apr 2010 17:11
Last Modified: 09 Dec 2017 12:55


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