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The antibody crossmatch in liver transplantation

Gordon, RD and Fung, JJ and Markus, B and Fox, I and Iwatsuki, S and Esquivel, CO and Tzakis, A and Todo, S and Starzl, TE (1986) The antibody crossmatch in liver transplantation. Surgery, 100 (4). 705 - 715. ISSN 0039-6060

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Abstract

Six hundred sixty-seven first, second, and third orthotopic liver allografts in 520 patients were reviewed to determine the effects of recipient panel-reactive antibody (PRA) and donor-recipient antibody crossmatch on 2-year patient and liver allograft survival rates. Neither a high panel-reactive antibody nor a positive crossmatch for donor-specific preformed antibody was associated with decreased patient or liver allograft survival for primary grafts or retransplants. Two patients have been given kidney transplants immediately after a liver allograft from a donor with whom each patient had a initial strongly positive donor-specific antibody crossmatch. The liver apparently removed or neutralized circulating anti-donor antibody, since the renal allografts functioned promptly and did not experience hyperacute rejection.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Gordon, RD
Fung, JJ
Markus, B
Fox, Iijf5@pitt.eduIJF5
Iwatsuki, S
Esquivel, CO
Tzakis, A
Todo, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 30 December 1986
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 100
Number: 4
Page Range: 705 - 715
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062119593, Starzl CV No. 675
Date Deposited: 08 Apr 2010 17:11
Last Modified: 24 Jan 2018 04:55
URI: http://d-scholarship.pitt.edu/id/eprint/4061

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