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Sex Hormone-Related Functions in Regenerating Male Rat Liver

Francavilla, A and Eagon, PK and DiLeo, A and Polimeno, L and Panella, C and Aquilino, AM and Ingrosso, M and Van Thiel, DH and Starzl, TE (1986) Sex Hormone-Related Functions in Regenerating Male Rat Liver. Gastroenterology, 91 (5). 1263 - 1270. ISSN 0016-5085

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Abstract

Sex hormone receptors were quantitated in normal male rat liver and in regenerating liver at several different times after partial (70%) hepatectomy. Both estrogen and androgen receptor content were altered dramatically by partial hepatectomy. Total hepatic content and nuclear retention of estrogen receptors increased, with the zenith evident 2 days after partial hepatectomy, corresponding to the zenith of mitotic index. Serum estradiol increased after 1 day, and reached a maximum at 3 days after surgery. In contrast, total and nuclear androgen receptor content demonstrated a massive decline at 1, 2, and 3 days after resection. Serum testosterone displayed a parallel decline. In addition, hepatic content of two androgen-responsive proteins was reduced to 15% and 13% of normal values during this period. The activity of these various proteins during regeneration of male rat liver is comparable to that observed in the liver of normal female rats. Taken together, these results indicate that partial hepatectomy induces a feminization of certain sexually dimorphic aspects of liver function in male rats. Furthermore, these data provide evidence that estrogens, but not androgens, may have an important role in the process of liver regeneration. © 1986, American Gastroenterological Association. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Francavilla, A
Eagon, PK
DiLeo, A
Polimeno, L
Panella, C
Aquilino, AM
Ingrosso, M
Van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1986
Date Type: Publication
Journal or Publication Title: Gastroenterology
Volume: 91
Number: 5
Page Range: 1263 - 1270
DOI or Unique Handle: 10.1016/s0016-5085(86)80026-9
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0016-5085
Other ID: uls-drl:31735062119577, Starzl CV No. 677
Date Deposited: 08 Apr 2010 17:11
Last Modified: 13 Oct 2017 21:59
URI: http://d-scholarship.pitt.edu/id/eprint/4063

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