Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Glucose metabolism during liver transplantation in dogs

DeWolf, AM and Kang, YG and Todo, S and Kam, I and Francavilla, AJ and Polimeno, L and Lynch, S and Starzl, TE (1987) Glucose metabolism during liver transplantation in dogs. Anesthesia and Analgesia, 66 (1). 76 - 80. ISSN 0003-2999

[img]
Preview
PDF
Accepted Version
Available under License : See the attached license file.

Download (1MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Arterial and hepatic venous blood levels of glucose were studied in 12 dogs during orthotopic liver transplantation peformed under ketamine anesthesia without exogenous glucose administration. During the early part of surgery, arterial blood glucose levels were stable: 161 ± 12 mg/dl (mean ± SEM) after laparotomy and 183 ± 16 mg/dl 5 min before the anhepatic stage. During the anhepatic stage, arterial blood glucose levels decreased progressively to 135 ± 9 and 88 ± 8 mg/dl, 5 min in the anhepatic stage and 5 min before reperfusion of the graft liver, respectively (P < 0.05). Reperfusion of the graft liver resulted in an increase in arterial glucose levels to 206 ± 17 and 240 ± 24 mg/dl, 5 and 30 min after reperfusion, respectively (P < 0.05). Hepatic venous blood glucose levels increased after reperfusion (405 ± 37 and 346 ± 41 mg/dl, 5 and 30 min after reperfusion, respectively) and were significantly higher than in arterial blood (P < 0.05). Arterial lasma insulin, measured in 5 animals, did not change significantly during the procedure, whereas plasma glucagon levels, stable during the preanhepatic and anhepatic stages, increased steadily after reperfusion of the graft liver, from 66.1 ± 14.2 to 108.4 ± 38.1 pg/ml (P < 0.05). This study shows that in dogs with ketamine anesthesia mild hypoglycemia occurs during the anhepatic stage of liver transplantation without exogenous glucose administration followed by hyperglycemia on reperfusion of the graft liver, possibly secondary to the release of glucose from the donor liver.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
DeWolf, AM
Kang, YG
Todo, S
Kam, I
Francavilla, AJ
Polimeno, L
Lynch, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 11 September 1987
Date Type: Publication
Journal or Publication Title: Anesthesia and Analgesia
Volume: 66
Number: 1
Page Range: 76 - 80
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0003-2999
Other ID: uls-drl:31735062118926, Starzl CV No. 698
Date Deposited: 08 Apr 2010 17:11
Last Modified: 13 Oct 2017 20:56
URI: http://d-scholarship.pitt.edu/id/eprint/4084

Metrics

Monthly Views for the past 3 years

Plum Analytics


Actions (login required)

View Item View Item