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Use of OKT3 with ciclosporin and steroids for reversal of acute kidney and liver allograft rejection

Fung, JJ and Demetris, AJ and Porter, KA (1987) Use of OKT3 with ciclosporin and steroids for reversal of acute kidney and liver allograft rejection. Nephron, 46 (SUPPL.). 19 - 33. ISSN 0028-2766

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Abstract

OKT3 monoclonal antibody therapy was added to preexisting baseline immunosuppressive treatment with ciclosporin and steroids to treat rejection in 52 recipients of cadaveric livers and 10 recipients of cadaveric kidneys. Rejection was controlled in 75% of patients treated, often after high-dose steroid therapy had failed. Rejection recurred during the 17-month follow-up period, after completion of OKT3, in only 25% of the patients who had responded. The safety and effectiveness of this monoclonal therapy, added to ciclosporin and steroids, has been established in this study.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Fung, JJ
Demetris, AJ
Porter, KA
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1987
Date Type: Publication
Journal or Publication Title: Nephron
Volume: 46
Number: SUPPL.
Page Range: 19 - 33
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0028-2766
Other ID: uls-drl:31735062118959, Starzl CV No. 701
Date Deposited: 08 Apr 2010 17:11
Last Modified: 14 Nov 2017 18:55
URI: http://d-scholarship.pitt.edu/id/eprint/4087

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