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Long-term results of cyclosporine-steroid therapy in 131 non-matched cadaveric renal transplants.

Gordon, Robert D and Starzl, Thomas E and Hakala, Thomas R and Taylor, Rodney J and Schroter, Gerhard PJ and Rosenthal, J Thomas and Well, Richard and Iwatsuki, Shunzaburo and Carpenter, Barbara J (1987) Long-term results of cyclosporine-steroid therapy in 131 non-matched cadaveric renal transplants. Clin Transplant, 1 (1). 44 - 48.

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Abstract

One-hundred-and-twenty-eight recipients of 131 consecutive, non-matched cadaver renal allografts were treated with cyclosporine and steroids. They have been followed for 4 to 6 yr. Cumulative patient survival at 1-yr was 92.2% and at 6yr it is 77.8%. Cumulative graft survival at 1-yr was 79.4% and at 6 yr it is 50.0%. After the high-risk 1st yr, the rate of graft loss was even and similar to that reported after the 1st yr for grafts treated with azathioprine and steroids. This indicates that cyclosporine nephrotoxicity has not had an obvious adverse effect on the survival of chronically functioning grafts. The results were better with primary grafting versus retransplantation, but were not significantly influenced by age, diabetes mellitus, or a delayed switch in patients from cyclosporine to azathioprine. We have concluded that cyclosporine-steroid therapy is safe and effective for long-term use after cadaveric renal transplantation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Gordon, Robert D
Starzl, Thomas Etes11@pitt.eduTES11
Hakala, Thomas R
Taylor, Rodney J
Schroter, Gerhard PJ
Rosenthal, J Thomas
Well, Richard
Iwatsuki, Shunzaburo
Carpenter, Barbara J
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1987
Date Type: Publication
Journal or Publication Title: Clin Transplant
Volume: 1
Number: 1
Page Range: 44 - 48
Institution: University of Pittsburgh
Refereed: Yes
Funders: NIDDK NIH HHS (R01 DK029961-19)
Other ID: uls-drl:31735062128560, Starzl CV No. 710
Date Deposited: 08 Apr 2010 17:12
Last Modified: 13 Oct 2017 17:55
URI: http://d-scholarship.pitt.edu/id/eprint/4096

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