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The Effects of Risk Alleles for Gestational Diabetes Mellitus on Type 2 Diabetes Mellitus in Samoan Women

Pantoni, Brittany Theresa (2021) The Effects of Risk Alleles for Gestational Diabetes Mellitus on Type 2 Diabetes Mellitus in Samoan Women. Master Essay, University of Pittsburgh.

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Gestational diabetes mellitus (GDM) is a type of diabetes diagnosed during pregnancy and is associated with increased risk of complications during pregnancy as well as long term health conditions for mother and child. Fifty percent of women affected with GDM will subsequently develop type two diabetes mellitus (T2DM). Because family history is a risk factor for GDM, previous research has explored the association of genetic risk factors and GDM. In general, Pacific Islanders have a high prevalence of GDM, and Samoans, specifically, have high rates of obesity, a risk factor for both T2DM and GDM. Thus, Samoans are at high-risk for development of T2DM and GDM, but the relationship of genetic variants and GDM in Samoans is unknown. Using data from a previous study, association between seven variants (reported to be associated with GDM in other populations) and T2DM status, as a surrogate for GDM. Because neither pregnancy nor GDM data were measured for females, males were used as the control group.
A variant in the CDKAL1 locus (rs7754840) was significantly associated with T2DM status (p<0.006). Compared to women who were homozygous for the G allele (GG), women who were heterozygous CG or homozygous CC had higher odds of developing T2DM (OR = 1.429, CI = 1.006–2.020, p < 0.006 and OR = 1.834, CI = 1.262–2.668, p < 0.006, respectively). The magnitude of the effect on diabetes status is comparable to previous reports. None of the SNVs were significantly associated with diabetes status in the men.
Additional studies should include pregnancy and GDM data to further investigate the effect of thee risk alleles and provide additional insights regarding genetic risk factors. This information would subsequently be used to identify women at higher risk for GDM and T2DM, develop intervention to mitigate this increased risk, and reduce development of T2DM and improve public health.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Pantoni, Brittany Theresabtp12@pitt.edubtp12
ContributionContributors NameEmailPitt UsernameORCID
Committee MemberKammerer, Candacecmk3@pitt.educmk3UNSPECIFIED
Committee MemberTerry, MarthaAnnmaterry@pitt.edumaterryUNSPECIFIED
Committee MemberMinster, Ryanrminster@pitt.eduminsterUNSPECIFIED
Centers: Other Centers, Institutes, Offices, or Units > Center for Global Health
Date: 30 April 2021
Date Type: Submission
Number of Pages: 39
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Human Genetics
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 12 May 2021 18:00
Last Modified: 12 May 2021 18:00

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