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Evaluation of HIV Status as a Risk Factor for COVID-19 Infection: A Combined Cohort Study

Perrotta, Cristina M. (2021) Evaluation of HIV Status as a Risk Factor for COVID-19 Infection: A Combined Cohort Study. Master Essay, University of Pittsburgh.

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Abstract

The HIV/AIDS epidemic in the United States and globally has proved to be a major public health issue and a topic of medical, scientific, and epidemiologic research for almost four decades. The HIV/AIDS pandemic, now considered an ongoing epidemic, changed the way many countries deal with public health associated issues, putting into place prevention measures, surveillance and other practices to prevent the spread of the disease while continuing to educate the public. Human immunodeficiency virus, or HIV, causes impaired immune function and increased susceptibility to opportunistic pathogens, preventing proper immune response, especially in those with advanced stage HIV disease or in those with poor adherence to antiretroviral therapy (ART). As of 2021, coronavirus disease 19 (COVID-19) caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly communicable and transmissible respiratory infection responsible for a deadly global pandemic. Immunocompromised individuals, such as those living with HIV, are most susceptible to COVID-19, potentially causing severe disease or death. Data collected by the Multicenter AIDS Cohort Study (MACS) and the Women’s Interagency HIV study (WIHS) during the height of the pandemic evaluated risk factors for HIV-positive and HIV-negative participants. This essay assesses the degree to which HIV infected individuals are at a higher risk for disease caused by the novel SARS-CoV-2 and whether a discrepancy exists between HIV-positive and HIV-negative individuals enrolled in the study. Investigation of potential differences between the groups could determine the relationship between HIV and COVID-19 and if coinfection influences outcomes. Further, susceptibly to COVID-19 and public health infrastructure will be described, and other demographic and geographical relationships will be highlighted.


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Details

Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Perrotta, Cristina M.cperrotta1@outlook.comcmp182
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairMartinson, Jeremy J.jmartins@pitt.edujmartinsUNSPECIFIED
Committee MemberFelter, Elizabeth M.emfelter@pitt.eduemfelterUNSPECIFIED
Committee MemberHa, Toantoan.ha@pitt.edutoan.haUNSPECIFIED
Centers: Other Centers, Institutes, Offices, or Units > Pitt Men's Study
Date: 12 May 2021
Date Type: Completion
Number of Pages: 45
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: HIV, HIV/AIDS, SARS-CoV-2, COVID-19
Date Deposited: 12 May 2021 17:58
Last Modified: 12 May 2021 17:58
URI: http://d-scholarship.pitt.edu/id/eprint/41056

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