Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Neutrophil-to-Lymphocyte Ratio Associations with Nosocomial Infections and Non-neurologic Organ Dysfunction in Moderate-to-Severe Traumatic Brain Injuries

Levochkina, Marina S (2021) Neutrophil-to-Lymphocyte Ratio Associations with Nosocomial Infections and Non-neurologic Organ Dysfunction in Moderate-to-Severe Traumatic Brain Injuries. Master's Thesis, University of Pittsburgh. (Unpublished)

This is the latest version of this item.

[img] PDF
Restricted to University of Pittsburgh users only until 20 May 2022.

Download (1MB) | Request a Copy

Abstract

Traumatic brain injuries (TBI) represent an immense public health encumbrance carrying high rates of mortality and chronic disability which leaves a severe cost burden on patient families. Establishing cost-effective, objective, and readily available biomarkers like neutrophil-to-lymphocyte ratios (NLR), is imperative for clinical prognostication in TBI patients. No TBI-specific studies have explored how NLR is affected by systemic secondary events, Non-neurologic organ dysfunction (NNOD) or infections. This study uncovered the prevalence of NNOD and infection and established significant relationships between infections, NNOD and NLR in a moderate-to-severe TBI population. Using multivariable logistic regression, we then explored and discovered significant relationships between early NNOD and infection development and increased levels of later NLR. Finally, we explored how all three of these factors were associated with six-month outcome and found that all three factors, NNOD, infections and NLR, were associated with unfavorable six-month outcome. This study sets the stage for future, hypothesis-driven studies investigating temporal dynamics of cellular immune responses and the causality of infections and NNOD.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Levochkina, Marina SMSL66@pitt.eduMSL66
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairMartinson, Jeremyjmartins@pitt.edujmartins
Committee MemberKitsios, Georgioskitsiosg@upmc.edu
Committee MemberMcVerry, Bryanmcverrybj@upmc.edu
Thesis AdvisorWagner, Amywagnerak@upmc.edu
Date: 20 May 2021
Date Type: Publication
Defense Date: 26 April 2021
Approval Date: 20 May 2021
Submission Date: 30 April 2021
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 59
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Clinical observational study
Date Deposited: 20 May 2021 20:35
Last Modified: 20 May 2021 20:35
URI: http://d-scholarship.pitt.edu/id/eprint/41069

Available Versions of this Item

  • Neutrophil-to-Lymphocyte Ratio Associations with Nosocomial Infections and Non-neurologic Organ Dysfunction in Moderate-to-Severe Traumatic Brain Injuries. (deposited 20 May 2021 20:35) [Currently Displayed]

Metrics

Monthly Views for the past 3 years

Plum Analytics


Actions (login required)

View Item View Item