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Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension

Rafikov, Ruslan and James, Joel and McClain, Nolan and Tofovic, Stevan P. and Rafikova, Olga (2019) Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension. Antioxidants, 8 (5). p. 135. ISSN 2076-3921

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Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease development and progression is unclear due to the complex nature of the PAH. Oxidative and nitrosative stresses are important contributors in PAH pathogenesis; however, the role of gender in redox homeostasis has been understudied. This review is aimed to overview the possible sex-specific mechanisms responsible for the regulation of the balance between oxidants and antioxidants in relation to PAH pathobiology.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Rafikov, Ruslan
James, Joel
McClain, Nolan
Tofovic, Stevan P.tofovic@pitt.edutofovic
Rafikova, Olga
Centers: Other Centers, Institutes, Offices, or Units > Vascular Medicine Institute
Date: 16 May 2019
Date Type: Publication
Journal or Publication Title: Antioxidants
Volume: 8
Number: 5
Publisher: MDPI AG
Page Range: p. 135
DOI or Unique Handle: 10.3390/antiox8050135
Schools and Programs: School of Medicine > Pharmacology and Chemical Biology
Refereed: Yes
Uncontrolled Keywords: pulmonary hypertension, gender difference, redox homeostasis, oxidation, antioxidants
ISSN: 2076-3921
Official URL:
Funders: National Institutes of Health
Article Type: Review
Date Deposited: 19 May 2021 18:06
Last Modified: 19 May 2021 18:06


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