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Antioxidant Approaches to Management of Ionizing Irradiation Injury

Greenberger, Joel and Kagan, Valerian and Bayir, Hulya and Wipf, Peter and Epperly, Michael (2015) Antioxidant Approaches to Management of Ionizing Irradiation Injury. Antioxidants, 4 (1). pp. 82-101. ISSN 2076-3921

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Ionizing irradiation induces acute and chronic injury to tissues and organs. Applications of antioxidant therapies for the management of ionizing irradiation injury fall into three categories: (1) radiation counter measures against total or partial body irradiation; (2) normal tissue protection against acute organ specific ionizing irradiation injury; and (3) prevention of chronic/late radiation tissue and organ injury. The development of antioxidant therapies to ameliorate ionizing irradiation injury began with initial studies on gene therapy using Manganese Superoxide Dismutase (MnSOD) transgene approaches and evolved into applications of small molecule radiation protectors and mitigators. The understanding of the multiple steps in ionizing radiation-induced cellular, tissue, and organ injury, as well as total body effects is required to optimize the use of antioxidant therapies, and to sequence such approaches with targeted therapies for the multiple steps in the irradiation damage response.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Greenberger, Joeljoelg@pitt.edujoelg
Kagan, Valeriankagan@pitt.edukagan
Bayir, Hulyahub22@pitt.eduhub22
Wipf, PeterWipfAdmin@pitt.eduWipfAdmin
Epperly, Michaelepperly@pitt.eduepperly
Centers: Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date: 23 January 2015
Date Type: Publication
Journal or Publication Title: Antioxidants
Volume: 4
Number: 1
Publisher: MDPI AG
Page Range: pp. 82-101
DOI or Unique Handle: 10.3390/antiox4010082
Schools and Programs: School of Medicine > Radiation Oncology
Refereed: Yes
Uncontrolled Keywords: ionizing irradiation, antioxidants, oxidative stress, mitochondrial mechanisms of apoptosis
ISSN: 2076-3921
Official URL:
Funders: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fanconi Anemia Research Foundation
Article Type: Research Article
Date Deposited: 19 May 2021 18:09
Last Modified: 19 May 2021 18:09


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