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Numerical and Experimental Investigations on Vocal Fold Approximation in Healthy and Simulated Unilateral Vocal Fold Paralysis

Li, Zheng and Wilson, Azure and Sayce, Lea and Avhad, Amit and Rousseau, Bernard and Luo, Haoxiang (2021) Numerical and Experimental Investigations on Vocal Fold Approximation in Healthy and Simulated Unilateral Vocal Fold Paralysis. Applied Sciences, 11 (4). p. 1817. ISSN 2076-3417

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We have developed a novel surgical/computational model for the investigation of unilat-eral vocal fold paralysis (UVFP) which will be used to inform future in silico approaches to improve surgical outcomes in type I thyroplasty. Healthy phonation (HP) was achieved using cricothyroid suture approximation on both sides of the larynx to generate symmetrical vocal fold closure. Following high-speed videoendoscopy (HSV) capture, sutures on the right side of the larynx were removed, partially releasing tension unilaterally and generating asymmetric vocal fold closure characteristic of UVFP (sUVFP condition). HSV revealed symmetric vibration in HP, while in sUVFP the sutured side demonstrated a higher frequency (10–11%). For the computational model, ex vivo magnetic resonance imaging (MRI) scans were captured at three configurations: non-approximated (NA), HP, and sUVFP. A finite-element method (FEM) model was built, in which cartilage displacements from the MRI images were used to prescribe the adduction, and the vocal fold deformation was simulated before the eigenmode calculation. The results showed that the frequency comparison between the two sides was consistent with observations from HSV. This alignment between the surgical and computational models supports the future application of these methods for the investigation of treatment for UVFP.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Li, Zheng
Sayce, Lea
Avhad, Amit
Luo, Haoxiang
Date: 18 February 2021
Date Type: Publication
Journal or Publication Title: Applied Sciences
Volume: 11
Number: 4
Publisher: MDPI AG
Page Range: p. 1817
DOI or Unique Handle: 10.3390/app11041817
Schools and Programs: School of Health and Rehabilitation Sciences > Communication Science and Disorders
Refereed: Yes
Uncontrolled Keywords: voice production, unilateral vocal fold paralysis, cricothyroid suture approximation, finite element modeling, vocal fold eigenfrequency
ISSN: 2076-3417
Official URL:
Funders: National Institute of Deafness and Other Communication Disorders, National Center For Advancing Translational Sciences of the National Institutes of Health
Article Type: Research Article
Date Deposited: 25 May 2021 19:41
Last Modified: 25 May 2021 19:41


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