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Prospects and Challenges of Translational Corneal Bioprinting

Fuest, Matthias and Yam, Gary Hin-Fai and Mehta, Jodhbir S. and Duarte Campos, Daniela F. (2020) Prospects and Challenges of Translational Corneal Bioprinting. Bioengineering, 7 (3). p. 71. ISSN 2306-5354

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Corneal transplantation remains the ultimate treatment option for advanced stromal and endothelial disorders. Corneal tissue engineering has gained increasing interest in recent years, as it can bypass many complications of conventional corneal transplantation. The human cornea is an ideal organ for tissue engineering, as it is avascular and immune-privileged. Mimicking the complex mechanical properties, the surface curvature, and stromal cytoarchitecure of the in vivo corneal tissue remains a great challenge for tissue engineering approaches. For this reason, automated biofabrication strategies, such as bioprinting, may offer additional spatial control during the manufacturing process to generate full-thickness cell-laden 3D corneal constructs. In this review, we discuss recent advances in bioprinting and biomaterials used for in vitro and ex vivo corneal tissue engineering, corneal cell-biomaterial interactions after bioprinting, and future directions of corneal bioprinting aiming at engineering a full-thickness human cornea in the lab.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Fuest, Matthias
Yam, Gary
Mehta, Jodhbir S.
Duarte Campos, Daniela F.
Date: 6 July 2020
Date Type: Publication
Journal or Publication Title: Bioengineering
Volume: 7
Number: 3
Publisher: MDPI AG
Page Range: p. 71
DOI or Unique Handle: 10.3390/bioengineering7030071
Schools and Programs: School of Medicine > Ophthalmology
Refereed: Yes
Uncontrolled Keywords: bioprinting, corneal tissue engineering, hydrogel, cell-biomaterial interaction, 3D
ISSN: 2306-5354
Official URL:
Article Type: Review
Date Deposited: 25 May 2021 19:36
Last Modified: 25 May 2021 19:36


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