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Non-Coding RNAs and Nucleosome Remodeling Complexes: An Intricate Regulatory Relationship

Patty, Benjamin J. and Hainer, Sarah J. (2020) Non-Coding RNAs and Nucleosome Remodeling Complexes: An Intricate Regulatory Relationship. Biology, 9 (8). p. 213. ISSN 2079-7737

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Eukaryotic genomes are pervasively transcribed, producing both coding and non-coding RNAs (ncRNAs). ncRNAs are diverse and a critical family of biological molecules, yet much remains unknown regarding their functions and mechanisms of regulation. ATP-dependent nucleosome remodeling complexes, in modifying chromatin structure, play an important role in transcriptional regulation. Recent findings show that ncRNAs regulate nucleosome remodeler activities at many levels and that ncRNAs are regulatory targets of nucleosome remodelers. Further, a series of recent screens indicate this network of regulatory interactions is more expansive than previously appreciated. Here, we discuss currently described regulatory interactions between ncRNAs and nucleosome remodelers and contextualize their biological functions.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Patty, Benjamin J.bjp86@pitt.edubjp86
Hainer, Sarah
Date: 7 August 2020
Date Type: Publication
Journal or Publication Title: Biology
Volume: 9
Number: 8
Publisher: MDPI AG
Page Range: p. 213
DOI or Unique Handle: 10.3390/biology9080213
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
Uncontrolled Keywords: chromatin, nucleosome remodeling, non-coding RNA (ncRNA), transcription, lncRNA, eRNA
ISSN: 2079-7737
Official URL:
Funders: National Institutes of Health
Article Type: Review
Date Deposited: 25 May 2021 19:34
Last Modified: 25 May 2021 19:34


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