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Bi- and Tri-Specific T Cell Engager-Armed Oncolytic Viruses: Next-Generation Cancer Immunotherapy

Guo, Zong Sheng and Lotze, Michael T. and Zhu, Zhi and Storkus, Walter J. and Song, Xiao-Tong (2020) Bi- and Tri-Specific T Cell Engager-Armed Oncolytic Viruses: Next-Generation Cancer Immunotherapy. Biomedicines, 8 (7). p. 204. ISSN 2227-9059

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Oncolytic viruses (OVs) are potent anti-cancer biologics with a bright future, having substantial evidence of efficacy in patients with cancer. Bi- and tri-specific antibodies targeting tumor antigens and capable of activating T cell receptor signaling have also shown great promise in cancer immunotherapy. In a cutting-edge strategy, investigators have incorporated the two independent anti-cancer modalities, transforming them into bi- or tri-specific T cell engager (BiTE or TriTE)-armed OVs for targeted immunotherapy. Since 2014, multiple research teams have studied this combinatorial strategy, and it showed substantial efficacy in various tumor models. Here, we first provide a brief overview of the current status of oncolytic virotherapy and the use of multi-specific antibodies for cancer immunotherapy. We then summarize progress on BiTE and TriTE antibodies as a novel class of cancer therapeutics in preclinical and clinical studies, followed by a discussion of BiTE- or TriTE-armed OVs for cancer therapy in translational models. In addition, T cell receptor mimics (TCRm) have been developed into BiTEs and are expected to greatly expand the application of BiTEs and BiTE-armed OVs for the effective targeting of intracellular tumor antigens. Future applications of such innovative combination strategies are emerging as precision cancer immunotherapies.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Guo, Zong Sheng
Lotze, Michael
Zhu, ZhiZHUZHI@pitt.eduZHUZHI
Storkus, Walter
Song, Xiao-Tong
Centers: Other Centers, Institutes, Offices, or Units > Hillman Cancer Center
Date: 10 July 2020
Date Type: Publication
Journal or Publication Title: Biomedicines
Volume: 8
Number: 7
Publisher: MDPI AG
Page Range: p. 204
DOI or Unique Handle: 10.3390/biomedicines8070204
Schools and Programs: School of Medicine > Surgery
Refereed: Yes
Uncontrolled Keywords: oncolytic virus, bispecific antibody, trispecific antibody, bispecific T cell engager, trispecific T cell engager, tumor antigen-specific T cells
ISSN: 2227-9059
Official URL:
Funders: UPMC Immune Transplant and Therapy Center, U.S. Department of Defense, Congressionally Directed Medical Research Programs
Article Type: Review
Date Deposited: 25 May 2021 19:40
Last Modified: 25 May 2021 19:40


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