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Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population

Lu, Yonghai and Wang, Yeli and Liang, Xu and Zou, Li and Ong, Choon and Yuan, Jian-Min and Koh, Woon-Puay and Pan, An (2019) Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population. Metabolites, 9 (1). p. 14. ISSN 2218-1989

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Abstract

We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A case-control study was nested within the Singapore Chinese Health Study. Participants included 144 cases with prevalent and 160 cases with incident type 2 diabetes and 304 controls. Cases and controls were individually matched on age, sex, and date of blood collection. Baseline serum levels of 9 essential and 10 non-essential amino acids were measured using liquid chromatography tandem mass spectrometry. We identified that five essential (isoleucine, leucine, lysine, phenylalanine, and valine) and five non-essential (alanine, glutamic acid, glutamine, glycine, and tyrosine) amino acids were associated with the prevalence of type 2 diabetes; four essential (isoleucine, leucine, tryptophan, and valine) and two non-essential (glutamine and tyrosine) amino acids were associated with the incidence of type 2 diabetes. Of these, valine and tyrosine independently led to a significant improvement in risk prediction of incident type 2 diabetes. This study demonstrates that both essential and non-essential amino acids were associated with the risk for prevalent and incident type 2 diabetes, and the findings could aid in diabetes risk assessment in this Chinese population.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lu, Yonghai
Wang, Yeli
Liang, Xu
Zou, Li
Ong, Choon
Yuan, Jian-Minyuanj@upmc.edu
Koh, Woon-Puay
Pan, An
Centers: Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute
Date: 15 January 2019
Date Type: Publication
Journal or Publication Title: Metabolites
Volume: 9
Number: 1
Publisher: MDPI AG
Page Range: p. 14
DOI or Unique Handle: 10.3390/metabo9010014
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
Uncontrolled Keywords: Essential amino acids, non-essential amino acids, type 2 diabetes, serum, LC-MS/MS
ISSN: 2218-1989
Official URL: http://dx.doi.org/10.3390/metabo9010014
Funders: National Medical Research Council Singapore, National Institutes of Health USA
Article Type: Research Article
Date Deposited: 26 May 2021 16:30
Last Modified: 26 May 2021 16:30
URI: http://d-scholarship.pitt.edu/id/eprint/41161

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