Lu, Yonghai and Wang, Yeli and Liang, Xu and Zou, Li and Ong, Choon and Yuan, Jian-Min and Koh, Woon-Puay and Pan, An
(2019)
Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population.
Metabolites, 9 (1).
p. 14.
ISSN 2218-1989
Abstract
We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A case-control study was nested within the Singapore Chinese Health Study. Participants included 144 cases with prevalent and 160 cases with incident type 2 diabetes and 304 controls. Cases and controls were individually matched on age, sex, and date of blood collection. Baseline serum levels of 9 essential and 10 non-essential amino acids were measured using liquid chromatography tandem mass spectrometry. We identified that five essential (isoleucine, leucine, lysine, phenylalanine, and valine) and five non-essential (alanine, glutamic acid, glutamine, glycine, and tyrosine) amino acids were associated with the prevalence of type 2 diabetes; four essential (isoleucine, leucine, tryptophan, and valine) and two non-essential (glutamine and tyrosine) amino acids were associated with the incidence of type 2 diabetes. Of these, valine and tyrosine independently led to a significant improvement in risk prediction of incident type 2 diabetes. This study demonstrates that both essential and non-essential amino acids were associated with the risk for prevalent and incident type 2 diabetes, and the findings could aid in diabetes risk assessment in this Chinese population.
Share
| Citation/Export: |
|
| Social Networking: |
|
Details
| Item Type: |
Article
|
| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Lu, Yonghai | | | | | Wang, Yeli | | | | | Liang, Xu | | | | | Zou, Li | | | | | Ong, Choon | | | | | Yuan, Jian-Min | yuanj@upmc.edu | | | | Koh, Woon-Puay | | | | | Pan, An | | | |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Pittsburgh Cancer Institute |
| Date: |
15 January 2019 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Metabolites |
| Volume: |
9 |
| Number: |
1 |
| Publisher: |
MDPI AG |
| Page Range: |
p. 14 |
| DOI or Unique Handle: |
10.3390/metabo9010014 |
| Schools and Programs: |
School of Public Health > Epidemiology |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Essential amino acids, non-essential amino acids, type 2 diabetes, serum, LC-MS/MS |
| ISSN: |
2218-1989 |
| Official URL: |
http://dx.doi.org/10.3390/metabo9010014 |
| Funders: |
National Medical Research Council Singapore, National Institutes of Health USA |
| Article Type: |
Research Article |
| Date Deposited: |
26 May 2021 16:30 |
| Last Modified: |
26 May 2021 16:30 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/41161 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Altmetric.com
Actions (login required)
 |
View Item |
![[feed]](/images/feed-icon-32x32.png){kind=icon}