Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases

Liu, Zhao and Tan, Roderick J. and Liu, Youhua (2020) The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases. Biomolecules, 10 (6). p. 960. ISSN 2218-273X

Published Version

Download (1MB) | Preview


Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an inactive zymogen, and proteolytic cleavage is required for its activation. MMP-7 is barely expressed in normal adult kidney but upregulated in acute kidney injury (AKI) and chronic kidney disease (CKD). The expression of MMP-7 is transcriptionally regulated by Wnt/β-catenin and other cues. As a secreted protein, MMP-7 is present and increased in the urine of patients, and its levels serve as a noninvasive biomarker for predicting AKI prognosis and monitoring CKD progression. Apart from degrading components of the extracellular matrix, MMP-7 also cleaves a wide range of substrates, such as E-cadherin, Fas ligand, and nephrin. As such, it plays an essential role in regulating many cellular processes, such as cell proliferation, apoptosis, epithelial-mesenchymal transition, and podocyte injury. The function of MMP-7 in kidney diseases is complex and context-dependent. It protects against AKI by priming tubular cells for survival and regeneration but promotes kidney fibrosis and CKD progression. MMP-7 also impairs podocyte integrity and induces proteinuria. In this review, we summarized recent advances in our understanding of the regulation, role, and mechanisms of MMP-7 in the pathogenesis of kidney diseases. We also discussed the potential of MMP-7 as a biomarker and therapeutic target in a clinical setting.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Liu, Zhao
Tan, Roderick
Liu, Youhuayhliu@pitt.eduyhliu
Date: 25 June 2020
Date Type: Publication
Journal or Publication Title: Biomolecules
Volume: 10
Number: 6
Publisher: MDPI AG
Page Range: p. 960
DOI or Unique Handle: 10.3390/biom10060960
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Uncontrolled Keywords: matrix metalloproteinase-7, fibrosis, proteinuria, acute kidney injury, chronic kidney disease, apoptosis
ISSN: 2218-273X
Official URL:
Funders: National Natural Science Foundation of China, National Institute of Health
Article Type: Review
Date Deposited: 26 May 2021 16:32
Last Modified: 26 May 2021 16:32


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item