Liu, Zhao and Tan, Roderick J. and Liu, Youhua
(2020)
The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases.
Biomolecules, 10 (6).
p. 960.
ISSN 2218-273X
Abstract
Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an inactive zymogen, and proteolytic cleavage is required for its activation. MMP-7 is barely expressed in normal adult kidney but upregulated in acute kidney injury (AKI) and chronic kidney disease (CKD). The expression of MMP-7 is transcriptionally regulated by Wnt/β-catenin and other cues. As a secreted protein, MMP-7 is present and increased in the urine of patients, and its levels serve as a noninvasive biomarker for predicting AKI prognosis and monitoring CKD progression. Apart from degrading components of the extracellular matrix, MMP-7 also cleaves a wide range of substrates, such as E-cadherin, Fas ligand, and nephrin. As such, it plays an essential role in regulating many cellular processes, such as cell proliferation, apoptosis, epithelial-mesenchymal transition, and podocyte injury. The function of MMP-7 in kidney diseases is complex and context-dependent. It protects against AKI by priming tubular cells for survival and regeneration but promotes kidney fibrosis and CKD progression. MMP-7 also impairs podocyte integrity and induces proteinuria. In this review, we summarized recent advances in our understanding of the regulation, role, and mechanisms of MMP-7 in the pathogenesis of kidney diseases. We also discussed the potential of MMP-7 as a biomarker and therapeutic target in a clinical setting.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
|
| Date: |
25 June 2020 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Biomolecules |
| Volume: |
10 |
| Number: |
6 |
| Publisher: |
MDPI AG |
| Page Range: |
p. 960 |
| DOI or Unique Handle: |
10.3390/biom10060960 |
| Schools and Programs: |
School of Medicine > Medicine |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
matrix metalloproteinase-7, fibrosis, proteinuria, acute kidney injury, chronic kidney disease, apoptosis |
| ISSN: |
2218-273X |
| Official URL: |
http://dx.doi.org/10.3390/biom10060960 |
| Funders: |
National Natural Science Foundation of China, National Institute of Health |
| Article Type: |
Review |
| Date Deposited: |
26 May 2021 16:32 |
| Last Modified: |
26 May 2021 16:32 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/41164 |
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