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Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases

Zhang, Xuejing and Connelly, Jaclyn and Chao, Yapeng and Wang, Qiming Jane (2021) Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases. Biomolecules, 11 (3). p. 483. ISSN 2218-273X

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Protein kinase D (PKD) is a family of serine/threonine protein kinases operating in the signaling network of the second messenger diacylglycerol. The three family members, PKD1, PKD2, and PKD3, are activated by a variety of extracellular stimuli and transduce cell signals affecting many aspects of basic cell functions including secretion, migration, proliferation, survival, angiogenesis, and immune response. Dysregulation of PKD in expression and activity has been detected in many human diseases. Further loss- or gain-of-function studies at cellular levels and in animal models provide strong support for crucial roles of PKD in many pathological conditions, including cancer, metabolic disorders, cardiac diseases, central nervous system disorders, inflammatory diseases, and immune dysregulation. Complexity in enzymatic regulation and function is evident as PKD isoforms may act differently in different biological systems and disease models, and understanding the molecular mechanisms underlying these differences and their biological significance in vivo is essential for the development of safer and more effective PKD-targeted therapies. In this review, to provide a global understanding of PKD function, we present an overview of the PKD family in several major human diseases with more focus on cancer-associated biological processes.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Zhang, Xuejingxuz20@pitt.eduxuz20
Connelly, Jaclynjac444@pitt.edujac444
Chao, Yapengyac63@pitt.eduyac63
Wang, Qiming Janeqjw1@pitt.eduqjw1
Date: 23 March 2021
Date Type: Publication
Journal or Publication Title: Biomolecules
Volume: 11
Number: 3
Publisher: MDPI AG
Page Range: p. 483
DOI or Unique Handle: 10.3390/biom11030483
Schools and Programs: School of Medicine > Pharmacology and Chemical Biology
Refereed: Yes
Uncontrolled Keywords: protein kinase D, diseases, cancer, cardiovascular diseases, CNS disorders, metabolic diseases
ISSN: 2218-273X
Official URL:
Funders: National Institutes of Health
Article Type: Review
Date Deposited: 28 May 2021 14:19
Last Modified: 28 May 2021 14:19


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