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A Homeostatic Model of Subjective Cognitive Decline

Mizuno, Akiko and Ly, Maria and Aizenstein, Howard (2018) A Homeostatic Model of Subjective Cognitive Decline. Brain Sciences, 8 (12). p. 228. ISSN 2076-3425 (In Press)

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Subjective Cognitive Decline (SCD) is possibly one of the earliest detectable signs of dementia, but we do not know which mental processes lead to elevated concern. In this narrative review, we will summarize the previous literature on the biomarkers and functional neuroanatomy of SCD. In order to extend upon the prevailing theory of SCD, compensatory hyperactivation, we will introduce a new model: the breakdown of homeostasis in the prediction error minimization system. A cognitive prediction error is a discrepancy between an implicit cognitive prediction and the corresponding outcome. Experiencing frequent prediction errors may be a primary source of elevated subjective concern. Our homeostasis breakdown model provides an explanation for the progression from both normal cognition to SCD and from SCD to advanced dementia stages.


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Item Type: Article
Status: In Press
CreatorsEmailPitt UsernameORCID
Ly, Mariamjl138@pitt.edumjl138
Aizenstein, Howardaizen@pitt.eduaizen
Date: 19 December 2018
Date Type: Publication
Journal or Publication Title: Brain Sciences
Volume: 8
Number: 12
Publisher: MDPI AG
Page Range: p. 228
DOI or Unique Handle: 10.3390/brainsci8120228
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
Uncontrolled Keywords: subjective cognitive decline, preclinical dementia, fMRI, compensation
ISSN: 2076-3425
Official URL:
Funders: National Institute of Health
Article Type: Review
Date Deposited: 28 May 2021 14:18
Last Modified: 28 May 2021 14:18


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