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Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring

Rathod, Richa S. and Ferguson, Carolyn and Seth, Amit and Baratta, Annalisa M. and Plasil, Sonja L. and Homanics, Gregg E. (2020) Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring. Brain Sciences, 10 (9). p. 658. ISSN 2076-3425

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We and others previously reported that paternal preconception chronic ethanol exposure leads to molecular, physiological, and behavioral changes in offspring including reduced ethanol consumption and preference relative to controls. The goal of the present study was to further explore the impact of paternal ethanol exposure on a wide variety of basal and drug-induced behavioral responses in first generation offspring. Adult male mice were exposed to chronic intermittent vapor ethanol or control conditions for 5–6 weeks before being mated with ethanol-naïve females to produce ethanol (E)- and control (C)-sired offspring. E-sired male offspring showed stress hyporesponsivity in a stress-induced hyperthermia assay and E-sired female offspring had reduced binge-like ethanol consumption in a drinking in the dark assay compared to C-sired offspring. E-sired offspring also showed altered sensitivity to a sedative/hypnotic dose of the GABAergic drug midazolam, but not ketamine or ethanol, in a loss of the righting response assay. E-sired offspring did not differ from controls in marble burying, novel object location, novel object recognition, social interaction, bottle-brush, novelty suppressed feeding, prepulse inhibition, every-other-day ethanol drinking, or home cage activity assays. This study adds to a growing body of literature suggesting that like in utero alcohol exposure, paternal preconception alcohol exposure can also have effects that persist and impact behavior of offspring.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Rathod, Richa S.rsrathod@pitt.edursrathod
Ferguson, Carolyncafst35@pitt.educafst35
Seth, Amitams649@pitt.eduams649
Baratta, Annalisa M.amb461@pitt.eduamb461
Plasil, Sonja L.
Homanics, Gregg
Centers: Other Centers, Institutes, Offices, or Units > Center for Neuroscience
Date: 22 September 2020
Date Type: Publication
Journal or Publication Title: Brain Sciences
Volume: 10
Number: 9
Publisher: MDPI AG
Page Range: p. 658
DOI or Unique Handle: 10.3390/brainsci10090658
Schools and Programs: School of Medicine > Anesthesiology
Refereed: Yes
Uncontrolled Keywords: alcohol, alcohol use disorders, chronic intermittent ethanol exposure, intergenerational inheritance, paternal alcohol
ISSN: 2076-3425
Official URL:
Funders: National Institutes of Health
Article Type: Research Article
Date Deposited: 04 Jun 2021 19:41
Last Modified: 04 Jun 2021 19:41


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