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Immunotherapy Advances for Epithelial Ovarian Cancer

Hartnett, Erin G. and Knight, Julia and Radolec, Mackenzy and Buckanovich, Ronald J. and Edwards, Robert P. and Vlad, Anda M. (2020) Immunotherapy Advances for Epithelial Ovarian Cancer. Cancers, 12 (12). p. 3733. ISSN 2072-6694

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New treatment modalities are needed in order to improve the prognosis of women diagnosed with epithelial ovarian cancer (EOC), the most aggressive gynecologic cancer type. Most ovarian tumors are infiltrated by immune effector cells, providing the rationale for targeted approaches that boost the existing or trigger new anti-tumor immune mechanisms. The field of immuno-oncology has experienced remarkable progress in recent years, although the results seen with single agent immunotherapies in several categories of solid tumors have yet to extend to ovarian cancer. The challenge remains to determine what treatment combinations are most suitable for this disease and which patients are likely to benefit and to identify how immunotherapy should be incorporated into EOC standard of care. We review here some of the most promising immune therapies for EOC and focus on those currently tested in clinical trials.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Hartnett, Erin G.
Knight, Juliajck81@pitt.edujck81
Buckanovich, Ronald J.rjb101@pitt.edurjb101
Edwards, Robert P.rpe1@pitt.edurpe1
Vlad, Anda M.anvst12@pitt.eduanvst12
Centers: Other Centers, Institutes, Offices, or Units > Magee-Women's Research Institute
Date: 11 December 2020
Date Type: Publication
Journal or Publication Title: Cancers
Volume: 12
Number: 12
Publisher: MDPI AG
Page Range: p. 3733
DOI or Unique Handle: 10.3390/cancers12123733
Schools and Programs: School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
Refereed: Yes
Uncontrolled Keywords: epithelial ovarian cancer, immune therapy, cancer vaccines, immune checkpoint inhibitors, CAR T cells, oncolytic viruses
ISSN: 2072-6694
Official URL:
Funders: Department of Defense Ovarian Cancer Research Program, National Institute of Health, Team Science Award from the Ovarian Cancer Research Fund Alliance
Article Type: Review
Date Deposited: 04 Jun 2021 17:24
Last Modified: 04 Jun 2021 17:24


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