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Liver transplantation before 1 year of age

Esquivel, CO and Koneru, B and Karrer, F and Todo, S and Iwatsuki, S and Gordon, RD and Makowka, L and Marsh, WJ and Starzl, TE (1987) Liver transplantation before 1 year of age. The Journal of Pediatrics, 110 (4). 545 - 548. ISSN 0022-3476

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Abstract

Since 1981, 20 infants younger than 1 year of age received 26 orthotopic liver transplants. Immunosuppression was with cyclosporine and corticosteroids. Thirteen (65%) of the reciplents were discharged from the hospital. To date, 12 (60%) of the 20 reciplents are surviving, with follow-up of 1 to 56 months (average 14 months). The 5-year acluarial survival is 53.8%. The allograft liver function in the majority of surviving infants is excellent. The predominant causes of mortality were primary nonfunction of the allograft (three patients) and sepsis (three). Major morbidity was caused by hepatic artery thrombosis (five patients), gastrointestinal complications (six), biliary tract complications (five), and bacterial and viral infections (13). Six patients underwent retransplantation; three of these six survived. Results could be improved by prevention of hepatic artery thrombosis, by decreasing the incidence of sepsis, and by procurement of more and better suited pediatric donors. © 1987 The C. V. Mosby Company.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Esquivel, CO
Koneru, B
Karrer, F
Todo, S
Iwatsuki, S
Gordon, RD
Makowka, L
Marsh, WJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1987
Date Type: Publication
Journal or Publication Title: The Journal of Pediatrics
Volume: 110
Number: 4
Page Range: 545 - 548
DOI or Unique Handle: 10.1016/s0022-3476(87)80545-0
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-3476
Other ID: uls-drl:31735062119353, Starzl CV No. 741
Date Deposited: 08 Apr 2010 17:12
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/4127

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