Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Molecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma

Zou, Han and Poore, Brad and Broniscer, Alberto and Pollack, Ian F. and Hu, Baoli (2020) Molecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma. Cancers, 12 (3). p. 643. ISSN 2072-6694

Published Version

Download (3MB) | Preview


Medulloblastoma, the most common pediatric malignant brain tumor, continues to have a high rate of morbidity and mortality in childhood. Recent advances in cancer genomics, single-cell sequencing, and sophisticated tumor models have revolutionized the characterization and stratification of medulloblastoma. In this review, we discuss heterogeneity associated with four major subgroups of medulloblastoma (WNT, SHH, Group 3, and Group 4) on the molecular and cellular levels, including histological features, genetic and epigenetic alterations, proteomic landscape, cell-of-origin, tumor microenvironment, and therapeutic approaches. The intratumoral molecular heterogeneity and intertumoral cellular diversity clearly underlie the divergent biology and clinical behavior of these lesions and highlight the future role of precision treatment in this devastating brain tumor in children.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Zou, Han
Poore, Brad
Broniscer, Albertoalb417@pitt.edualb417
Pollack, Ian F.ipollack@pitt.eduipollack
Hu, Baolibaolihu@pitt.edubaolihu
Centers: Other Centers, Institutes, Offices, or Units > Hillman Cancer Center
Date: 10 March 2020
Date Type: Publication
Journal or Publication Title: Cancers
Volume: 12
Number: 3
Publisher: MDPI AG
Page Range: p. 643
DOI or Unique Handle: 10.3390/cancers12030643
Schools and Programs: School of Medicine > Neurological Surgery
Refereed: Yes
Uncontrolled Keywords: medulloblastoma, molecular subgroups, genetic and epigenetic heterogeneity, intertumoral diversity, clinical trials
ISSN: 2072-6694
Official URL:
Funders: Matthew Larson Foundation, V Foundation
Article Type: Review
Date Deposited: 11 Jun 2021 19:18
Last Modified: 11 Jun 2021 19:18


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item