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Emerging Role of Circulating Tumor Cells in Gastric Cancer

Thanh Huong, Phung and Gurshaney, Sanjeev and Thanh Binh, Nguyen and Gia Pham, Anh and Hoang Nguyen, Huy and Thanh Nguyen, Xuan and Pham-The, Hai and Tran, Phuong-Thao and Truong Vu, Khanh and Xuan Duong, Nhuong and Pelucchi, Claudio and La Vecchia, Carlo and Boffetta, Paolo and Nguyen, Hung D. and Luu, Hung N. (2020) Emerging Role of Circulating Tumor Cells in Gastric Cancer. Cancers, 12 (3). p. 695. ISSN 2072-6694

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With over 1 million incidence cases and more than 780,000 deaths in 2018, gastric cancer (GC) was ranked as the 5th most common cancer and the 3rd leading cause of cancer deaths worldwide. Though several biomarkers, including carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9), and cancer antigen 72-4 (CA72-4), have been identified, their diagnostic accuracies were modest. Circulating tumor cells (CTCs), cells derived from tumors and present in body fluids, have recently emerged as promising biomarkers, diagnostically and prognostically, of cancers, including GC. In this review, we present the landscape of CTCs from migration, to the presence in circulation, biologic properties, and morphologic heterogeneities. We evaluated clinical implications of CTCs in GC patients, including diagnosis, prognosis, and therapeutic management, as well as their application in immunotherapy. On the one hand, major challenges in using CTCs in GC were analyzed, from the differences of cut-off values of CTC positivity, to techniques used for sampling, storage conditions, and CTC molecular markers, as well as the unavailability of relevant enrichment and detection techniques. On the other hand, we discussed future perspectives of using CTCs in GC management and research, including the use of circulating tumor microembolies; of CTC checkpoint blockade in immunotherapy; and of organoid models. Despite the fact that there are remaining challenges in techniques, CTCs have potential as novel biomarkers and/or a non-invasive method for diagnostics, prognostics, and treatment monitoring of GC, particularly in the era of precision medicine.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Thanh Huong, Phung
Gurshaney, Sanjeev
Thanh Binh, Nguyen
Gia Pham, Anh
Hoang Nguyen, Huy
Thanh Nguyen, Xuan
Pham-The, Hai
Tran, Phuong-Thao
Truong Vu, Khanh
Xuan Duong, Nhuong
Pelucchi, Claudio
La Vecchia, Carlo
Boffetta, Paolo
Nguyen, Hung D.
Luu, Hung N.hnl11@pitt.eduhnl11
Centers: Other Centers, Institutes, Offices, or Units > Hillman Cancer Center
Date: 15 March 2020
Date Type: Publication
Journal or Publication Title: Cancers
Volume: 12
Number: 3
Publisher: MDPI AG
Page Range: p. 695
DOI or Unique Handle: 10.3390/cancers12030695
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
Uncontrolled Keywords: circulating tumor cells, gastric cancer, diagnostic, prognostic, treatment
ISSN: 2072-6694
Official URL:
Funders: University of Central Florida., University of Pittsburgh Medical Center
Article Type: Review
Date Deposited: 11 Jun 2021 19:17
Last Modified: 11 Jun 2021 19:17


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